{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:32:45Z","timestamp":1788478365825,"version":"build-2803163510"},"reference-count":30,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Care"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We sought to investigate the short- and long-term effects of prone positioning (PP) on ventilation\/perfusion matching in patients with ARDS using contrast-enhanced electrical impedance tomography (EIT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      EIT measurements were performed in 18 mechanically ventilated subjects with ARDS before PP (supine position [SP]), 1 h after turning subjects to PP (PP\n                      <jats:sub>1<\/jats:sub>\n                      ), 3 h after PP (PP\n                      <jats:sub>3<\/jats:sub>\n                      ), 9 h after (PP\n                      <jats:sub>9<\/jats:sub>\n                      ), 16 h after PP (PP\n                      <jats:sub>16<\/jats:sub>\n                      ; the end of PP), and 3 h after returning to the supine position (Re-SP\n                      <jats:sub>3<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:inline-formula>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" overflow=\"scroll\">\n                          <mml:mrow>\n                            <mml:mrow>\n                              <mml:msub>\n                                <mml:mi mathvariant=\"normal\">P<\/mml:mi>\n                                <mml:mrow>\n                                  <mml:mi mathvariant=\"normal\">a<\/mml:mi>\n                                  <mml:mrow>\n                                    <mml:msub>\n                                      <mml:mi mathvariant=\"normal\">O<\/mml:mi>\n                                      <mml:mn>2<\/mml:mn>\n                                    <\/mml:msub>\n                                  <\/mml:mrow>\n                                <\/mml:mrow>\n                              <\/mml:msub>\n                            <\/mml:mrow>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:inline-formula>\n                      \/\n                      <jats:inline-formula>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" overflow=\"scroll\">\n                          <mml:mrow>\n                            <mml:mrow>\n                              <mml:msub>\n                                <mml:mi mathvariant=\"normal\">F<\/mml:mi>\n                                <mml:mrow>\n                                  <mml:mi mathvariant=\"normal\">I<\/mml:mi>\n                                  <mml:mrow>\n                                    <mml:msub>\n                                      <mml:mi mathvariant=\"normal\">O<\/mml:mi>\n                                      <mml:mn>2<\/mml:mn>\n                                    <\/mml:msub>\n                                  <\/mml:mrow>\n                                <\/mml:mrow>\n                              <\/mml:msub>\n                            <\/mml:mrow>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:inline-formula>\n                      increased gradually during the PP period (110.68 vs 158.44 vs 210.15 vs 215.22 vs 236.04 vs 163.77\u2009mm\u2009Hg, mean values at SP, PP\n                      <jats:sub>1<\/jats:sub>\n                      , PP\n                      <jats:sub>3<\/jats:sub>\n                      , PP\n                      <jats:sub>9<\/jats:sub>\n                      , PP\n                      <jats:sub>16<\/jats:sub>\n                      , and Re-SP\n                      <jats:sub>3<\/jats:sub>\n                      , respectively\n                      <jats:italic toggle=\"yes\">, P<\/jats:italic>\n                      &lt; .001). Global ventilation\/perfusion matched percent significantly increased within PP duration (54.13% vs 63.15% vs 63.02% vs 63.75% vs 66.63% vs 57.42,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .005). Compared with SP, dorsal ventilation significantly increased at PP\n                      <jats:sub>1<\/jats:sub>\n                      (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) and increased gradually during PP. However, the dorsal flow commenced to improve at PP\n                      <jats:sub>9<\/jats:sub>\n                      and persisted in enhancement until PP\n                      <jats:sub>16<\/jats:sub>\n                      (40.61% vs 48.78% vs 50.56%, mean values at PP\n                      <jats:sub>3<\/jats:sub>\n                      , PP\n                      <jats:sub>9<\/jats:sub>\n                      , and PP\n                      <jats:sub>16<\/jats:sub>\n                      , respectively\n                      <jats:italic toggle=\"yes\">, P<\/jats:italic>\n                      &lt; .05). There was a significant reduction in global Shunt-EIT percentage within PP duration, primarily localized in the dorsal area. Dead Space-EIT percentage remained unchanged during PP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Oxygenation remained improved or maintained throughout the 16-h duration of PP. Ventilation is susceptible to immediate gravitational effects; however, changes in blood flow may occur later after 9 h, which supports prolonged PP treatment. The shunt continuously decreases, but no significant changes were observed for dead space.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>ClinicalTrials.gov, NCT04725227. Registered on January 25, 2021.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/respcare.12247","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T03:14:16Z","timestamp":1741144456000},"page":"821-829","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Influence of Prone Position on Regional Ventilation\/Perfusion Matching in Patients With ARDS Over Time"],"prefix":"10.1177","volume":"70","author":[{"given":"Yuxian","family":"Wang","sequence":"first","affiliation":[{"name":"Drs. Wang, Song, Lin, Zheng and Zhong are affiliated with Department of Critical Care Medicine, Zhongshan Hospital of Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqiong","family":"Song","sequence":"additional","affiliation":[{"name":"Drs. Wang, Song, Lin, Zheng and Zhong are affiliated with Department of Critical Care Medicine, Zhongshan Hospital of Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyao","family":"Lin","sequence":"additional","affiliation":[{"name":"Drs. Wang, Song, Lin, Zheng and Zhong are affiliated with Department of Critical Care Medicine, Zhongshan Hospital of Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Drs. Wang, Song, Lin, Zheng and Zhong are affiliated with Department of Critical Care Medicine, Zhongshan Hospital of Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Dr. Zhao is affiliated with School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China."},{"name":"Dr. Zhao is affiliated with Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China."},{"name":"Dr. Zhao is affiliated with Institute of Technical Medicine, Furtwangen University, Villingen-Schwenningen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Drs. Wang, Song, Lin, Zheng and Zhong are affiliated with Department of Critical Care Medicine, Zhongshan Hospital of Fudan University, Shanghai, China."},{"name":"Dr. Zhong is affiliated with Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201207-1279OC"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200501-004OC"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31818094a9"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202007-2957OC"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.12.039"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04021-0"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214103"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1977.115.4.559"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.2.97-04023"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-023-07050-7"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202311-2011ST"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202008-3058LE"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005450"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004296"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.7509706"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-023-07280-6"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01090.2010"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004386"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03615-4"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318287f6e7"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181d8cb51"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.1.8111603"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052052"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3066-x"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.2.620"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1770059"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051050"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.6.9907067"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202003-0775IM"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000230"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/respcare.12247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/respcare.12247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/respcare.12247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:36:44Z","timestamp":1777685804000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/respcare.12247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1089\/respcare.12247"],"URL":"https:\/\/doi.org\/10.1089\/respcare.12247","relation":{},"ISSN":["1943-3654","1943-3654"],"issn-type":[{"value":"1943-3654","type":"print"},{"value":"1943-3654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}