{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:17:22Z","timestamp":1788182242198,"version":"build-2803163510"},"reference-count":19,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Care"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Children admitted to the general in-patient unit for status asthmaticus may not receive the first albuterol treatment on schedule. We sought to determine if a difference in timing between the scheduled and actual first dose of albuterol is associated with care escalation to the pediatric intensive care unit (PICU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We conducted a single-center case\u2013control study of children 2\u201318\u2009years admitted from the emergency department to the general in-patient unit for status asthmaticus. Cases were defined as children who required transfer to the PICU within 24 hours of admission. Groups were compared using Fisher\u2019s exact or Mann\u2013Whitney\n                      <jats:italic toggle=\"yes\">U<\/jats:italic>\n                      tests. Firth multivariable logistic regression estimated the adjusted association between dose timing and odds of transfer to the PICU.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Groups did not differ by demographics, comorbidities, or asthma severity risk factors. The median (IQR) time difference between the scheduled and administered first dose of albuterol was 0 (\u221214 to 63) min for cases and 16 (\u22126 to 42) min for controls\n                      <jats:italic toggle=\"yes\">(P<\/jats:italic>\n                      = .43). Fifty percent of cases received delayed treatment compared with 63% of controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .26). The adjusted analyses demonstrated that as the time difference between scheduled and administered albuterol increased by 1 min, odds of care escalation to the PICU remained the same (adjusted odds ratio 1.0, 95% CI: 0.9\u20131.0,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .18).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Receiving first albuterol treatment in the general in-patient unit at a time different than scheduled was not associated with increased odds of transfer to PICU.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/respcare.12340","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T04:36:38Z","timestamp":1745901398000},"page":"1248-1256","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Timing of Albuterol and Care Escalation to the Pediatric Intensive Care Unit Within 24 Hours of Admission for Status Asthmaticus"],"prefix":"10.1177","volume":"70","author":[{"given":"Zoha S.","family":"Ahmed","sequence":"first","affiliation":[{"name":"Dr. Ahmed is affiliated with Children\u2019s Hospital Los Angeles, Los Angeles, California, USA."},{"name":"Drs. Ahmed, Morrison, Fierstein, and Jabre are affiliated with Johns Hopkins All Children\u2019s Hospital, St. Petersburg, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Drs. Ahmed, Morrison, Fierstein, and Jabre are affiliated with Johns Hopkins All Children\u2019s Hospital, St. Petersburg, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie L.","family":"Fierstein","sequence":"additional","affiliation":[{"name":"Drs. Ahmed, Morrison, Fierstein, and Jabre are affiliated with Johns Hopkins All Children\u2019s Hospital, St. Petersburg, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Jabre","sequence":"additional","affiliation":[{"name":"Drs. Ahmed, Morrison, Fierstein, and Jabre are affiliated with Johns Hopkins All Children\u2019s Hospital, St. Petersburg, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2017-0003"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-016-1019-4"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/pq9.0000000000000041"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06626"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-3026"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1863\/7\/jss.v042.i08"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010240"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1047"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/80.1.27"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00174-2022"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2019.1680998"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0502-0"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2014.09.005"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210939"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.11.639"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2011.12.02"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-234"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32835b590a"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2023-064344MA"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/respcare.12340","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/respcare.12340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/respcare.12340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:26:46Z","timestamp":1788179206000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/respcare.12340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1089\/respcare.12340"],"URL":"https:\/\/doi.org\/10.1089\/respcare.12340","relation":{},"ISSN":["1943-3654","1943-3654"],"issn-type":[{"value":"1943-3654","type":"print"},{"value":"1943-3654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]}}}