{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:17:24Z","timestamp":1788182244770,"version":"build-2803163510"},"reference-count":31,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Care"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The relationship between left-ventricular hypertrophy (LVH), left-ventricular mass index (LVMI), body mass index (BMI), and their corresponding pulmonary function test parameters remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this prospective observational study, we assessed the pulmonary function of subjects with LVH. The severity of airway obstruction was graded into five levels using the FEV\n                      <jats:sub>1<\/jats:sub>\n                      % predicted value and the prevalence of obstruction with left-ventricular mass was also correlated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Our study included 289 subjects [142 (49.1%) LVH and 147 (50.8%) non-LVH]. The mean age of subjects with LVH was 56 \u00b1 17.8\u2009years. Sixty-two subjects with normal BMI had LVH. One-hundred forty-two subjects with LVH underwent spirometry; 9 (6.3%), 16 (11.3%), 18 (12.7%), 49 (34.5%), and 48 (33.8%) had mild, moderate, moderately severe, severe, and very severe obstruction before the administration of bronchodilator, respectively. After bronchodilator administration, the numbers (n%) were 13 (9.15%), 17 (11.9%), 27 (19%), 52 (36.6%), and 30 (21.1%), respectively. There was a strong inverse relationship (r = \u22120.87, r = \u22120.86) for pre bronchodilator and post bronchodilator, respectively; R\n                      <jats:sup>2<\/jats:sup>\n                      = 0.76 and R\n                      <jats:sup>2<\/jats:sup>\n                      = 0.74 for pre and post bronchodilator respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001 for both) between LVMI and FEV\n                      <jats:sub>1<\/jats:sub>\n                      %.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>LVH was associated with high prevalence of obstructive pulmonary disease. The severity of obstruction was correlated with left-ventricular mass. The early screening of such underlying obstruction may help to reduce the risk of further complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/respcare.12550","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T04:59:17Z","timestamp":1746766757000},"page":"1294-1300","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Airway Obstruction in Patients With Left-Ventricular Hypertrophy"],"prefix":"10.1177","volume":"70","author":[{"given":"Priyavardhan","family":"Mishra","sequence":"first","affiliation":[{"name":"Mr. Mishra and Mr. Biswal are affiliated with School of Medicine, DY Patil Deemed to be University School of Medicine, Navi Mumbai, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anant","family":"Patil","sequence":"additional","affiliation":[{"name":"Dr. Patil is affiliated with Department of Pharmacology, DY Patil Deemed to be University School of Medicine, Navi Mumbai, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Sarangdhar","sequence":"additional","affiliation":[{"name":"Drs. Sarangdhar, Kondisetti, and Nair are affiliated with the Department of Pulmonary Medicine, DY Patil Deemed to be University School of Medicine, Navi Mumbai, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pannag Bhushan","family":"Biswal","sequence":"additional","affiliation":[{"name":"Mr. Mishra and Mr. Biswal are affiliated with School of Medicine, DY Patil Deemed to be University School of Medicine, Navi Mumbai, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Kondisetti","sequence":"additional","affiliation":[{"name":"Drs. Sarangdhar, Kondisetti, and Nair are affiliated with the Department of Pulmonary Medicine, DY Patil Deemed to be University School of Medicine, Navi Mumbai, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girija","family":"Nair","sequence":"additional","affiliation":[{"name":"Drs. Sarangdhar, Kondisetti, and Nair are affiliated with the Department of Pulmonary Medicine, DY Patil Deemed to be University School of Medicine, Navi Mumbai, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-0062"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12977"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12574-020-00508-3"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3666\/0\/abc.20210868"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2011.104"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012039.pub3"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010228"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2006.10.018"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S285812"},{"key":"e_1_3_4_11_2","volume-title":"StatPearls [Internet]","author":"David S","year":"2025","unstructured":"David S, , Goldin J, , Edwards CW. 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