{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:44:25Z","timestamp":1792190665959,"version":"4.4.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Care"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We sought to analyze the prevalence of patient-ventilator asynchronies in subjects with hypoxemic respiratory failure because of COVID-19 ARDS and their association with clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a two-center observational cohort study using prospectively collected real-world data. We included adult subjects with COVID-19 ARDS who required mechanical ventilation for more than 48 hours. We analyzed the prevalence, characteristics, and clusters of the following patient-ventilator asynchronies detected using dedicated software on continuous respiratory recordings obtained from ventilators over the duration of mechanical ventilation (Better Care, Sabadell, Spain): double triggering, ineffective efforts (IE), and reverse triggering with and without breath-stacking (BS). The outcome measures evaluated were duration of invasive mechanical ventilation, ICU stay, and ICU mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We analyzed 82 subjects with COVID-19 ARDS. Over the complete duration of mechanical ventilation, the most frequent asynchronies and related clusters were reverse triggering without BS (0.72% of breaths [interquartile range (IQR), 0.17\u20133.07]) and 4.6 clusters\/d [IQR, 2.0\u20138.1] and double triggering (0.44% of breaths [IQR, 0.19\u20130.80]) and 4.6 clusters\/d [IQR, 2.1\u20137.3]. The use of neuromuscular blockers was associated with a lower prevalence of double triggering and IE, but reverse triggering was not significantly reduced. Double triggering significantly increased with longer mechanical ventilation time, whereas reverse trigger significantly decreased during this period. Double triggering and clusters of double triggering were independently associated with longer mechanical ventilation duration and better ICU survival, whereas clusters of reverse triggering with BS were associated with longer duration of mechanical ventilation and ICU stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Reverse triggering was the most prevalent asynchrony in subjects with ARDS COVID-19, decreased over time, and was followed by double triggering. Survivors had a higher prevalence of double triggering and clusters of double triggering, mostly occurring during spontaneous modes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/respcare.12673","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T19:37:26Z","timestamp":1748547446000},"page":"1357-1366","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Longitudinal Characterization of Patient-Ventilator Asynchronies in Acute Hypoxemic Respiratory Failure"],"prefix":"10.1177","volume":"70","author":[{"given":"Candelaria","family":"de Haro","sequence":"first","affiliation":[{"name":"Dr. de Haro, Dr. Roca, Dr. Blanch, and Ms. Gom\u00e0 are affiliated with Critical Care Department, Parc Taul\u00ed Hospital Universitari, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain."},{"name":"Dr. de Haro, Dr. Batlle, Subir\u00e0, Dr. L\u00f3pez-Aguilar, Dr. Fern\u00e1ndez, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Gom\u00e0, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain."},{"name":"Dr. de Haro, Dr. L\u00f3pez-Aguilar, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Fern\u00e1ndez-Gonzalo, Ms. Estela, Ms. Godoy-Gonz\u00e1lez, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Grup d\u2019Investigaci\u00f3 Traslacional del Pacient Cr\u00edtic, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Sabadell, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Xifra-Porxas","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. Batlle, Subir\u00e0, Dr. L\u00f3pez-Aguilar, Dr. Fern\u00e1ndez, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Gom\u00e0, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain."},{"name":"Dr. de Haro, Dr. L\u00f3pez-Aguilar, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Fern\u00e1ndez-Gonzalo, Ms. Estela, Ms. Godoy-Gonz\u00e1lez, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Grup d\u2019Investigaci\u00f3 Traslacional del Pacient Cr\u00edtic, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Sabadell, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Batlle","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. Batlle, Subir\u00e0, Dr. L\u00f3pez-Aguilar, Dr. Fern\u00e1ndez, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Gom\u00e0, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain."},{"name":"Drs. Batlle and Fern\u00e1ndez are affiliated with Critical Care Department, Althaia Xarxa Assistencial Universitaria de Manresa, Manresa, Spain."},{"name":"Drs. Batlle and Fern\u00e1ndez are affiliated with IRIS\u2014Catalunya Central and Grup de Recerca de Malalt Cr\u00edtic, Manresa, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Sarlabous","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. Batlle, Subir\u00e0, Dr. L\u00f3pez-Aguilar, Dr. Fern\u00e1ndez, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Gom\u00e0, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain."},{"name":"Dr. de Haro, Dr. L\u00f3pez-Aguilar, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Fern\u00e1ndez-Gonzalo, Ms. Estela, Ms. Godoy-Gonz\u00e1lez, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Grup d\u2019Investigaci\u00f3 Traslacional del Pacient Cr\u00edtic, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Sabadell, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Santos-Pulp\u00f3n","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. Batlle, Subir\u00e0, Dr. L\u00f3pez-Aguilar, Dr. Fern\u00e1ndez, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Gom\u00e0, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain."},{"name":"Dr. de Haro, Dr. L\u00f3pez-Aguilar, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Fern\u00e1ndez-Gonzalo, Ms. Estela, Ms. Godoy-Gonz\u00e1lez, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Grup d\u2019Investigaci\u00f3 Traslacional del Pacient Cr\u00edtic, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Sabadell, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Mora","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. Batlle, Subir\u00e0, Dr. L\u00f3pez-Aguilar, Dr. Fern\u00e1ndez, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Gom\u00e0, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain."},{"name":"Dr. de Haro, Dr. L\u00f3pez-Aguilar, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Fern\u00e1ndez-Gonzalo, Ms. Estela, Ms. Godoy-Gonz\u00e1lez, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Grup d\u2019Investigaci\u00f3 Traslacional del Pacient Cr\u00edtic, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Sabadell, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Su\u00f1ol","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. Batlle, Subir\u00e0, Dr. L\u00f3pez-Aguilar, Dr. Fern\u00e1ndez, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Gom\u00e0, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain."},{"name":"Dr. de Haro, Dr. L\u00f3pez-Aguilar, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Fern\u00e1ndez-Gonzalo, Ms. Estela, Ms. Godoy-Gonz\u00e1lez, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Grup d\u2019Investigaci\u00f3 Traslacional del Pacient Cr\u00edtic, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Sabadell, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Gom\u00e0","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. Roca, Dr. Blanch, and Ms. Gom\u00e0 are affiliated with Critical Care Department, Parc Taul\u00ed Hospital Universitari, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain."},{"name":"Dr. de Haro, Dr. Batlle, Subir\u00e0, Dr. L\u00f3pez-Aguilar, Dr. Fern\u00e1ndez, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Gom\u00e0, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Estela","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. L\u00f3pez-Aguilar, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Fern\u00e1ndez-Gonzalo, Ms. Estela, Ms. Godoy-Gonz\u00e1lez, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Grup d\u2019Investigaci\u00f3 Traslacional del Pacient Cr\u00edtic, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Sabadell, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Subir\u00e0","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. Batlle, Subir\u00e0, Dr. L\u00f3pez-Aguilar, Dr. Fern\u00e1ndez, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Gom\u00e0, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain."},{"name":"Dr. Subir\u00e0 is affiliated with Hospital de la Santa Creu i Sant Pau, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"L\u00f3pez-Aguilar","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. Batlle, Subir\u00e0, Dr. L\u00f3pez-Aguilar, Dr. Fern\u00e1ndez, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Gom\u00e0, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain."},{"name":"Dr. de Haro, Dr. L\u00f3pez-Aguilar, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Fern\u00e1ndez-Gonzalo, Ms. Estela, Ms. Godoy-Gonz\u00e1lez, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Grup d\u2019Investigaci\u00f3 Traslacional del Pacient Cr\u00edtic, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Sabadell, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol","family":"Fern\u00e1ndez-Gonzalo","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. L\u00f3pez-Aguilar, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Fern\u00e1ndez-Gonzalo, Ms. Estela, Ms. Godoy-Gonz\u00e1lez, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Grup d\u2019Investigaci\u00f3 Traslacional del Pacient Cr\u00edtic, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Sabadell, Spain."},{"name":"Ms. Fern\u00e1ndez-Gonzalo is affiliated with Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Godoy-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. L\u00f3pez-Aguilar, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Fern\u00e1ndez-Gonzalo, Ms. Estela, Ms. Godoy-Gonz\u00e1lez, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Grup d\u2019Investigaci\u00f3 Traslacional del Pacient Cr\u00edtic, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Sabadell, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. Batlle, Subir\u00e0, Dr. L\u00f3pez-Aguilar, Dr. Fern\u00e1ndez, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Gom\u00e0, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain."},{"name":"Drs. Batlle and Fern\u00e1ndez are affiliated with Critical Care Department, Althaia Xarxa Assistencial Universitaria de Manresa, Manresa, Spain."},{"name":"Drs. Batlle and Fern\u00e1ndez are affiliated with IRIS\u2014Catalunya Central and Grup de Recerca de Malalt Cr\u00edtic, Manresa, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudys","family":"Magrans","sequence":"additional","affiliation":[{"name":"Mr. Magrans is affiliated with Better Care, Sabadell, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Telias","sequence":"additional","affiliation":[{"name":"Dr. Telias and Prof. Brochard are affiliated with Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Canada."},{"name":"Dr. Telias and Prof. Brochard are affiliated with Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada."},{"name":"Dr. Telias is affiliated with Division of Respirology, Department of Medicine, University Health Network and Sinai Health System, Toronto, 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Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Brochard","sequence":"additional","affiliation":[{"name":"Dr. Telias and Prof. Brochard are affiliated with Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Canada."},{"name":"Dr. Telias and Prof. Brochard are affiliated with Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llu\u00eds","family":"Blanch","sequence":"additional","affiliation":[{"name":"Dr. de Haro, Dr. Roca, Dr. Blanch, and Ms. Gom\u00e0 are affiliated with Critical Care Department, Parc Taul\u00ed Hospital Universitari, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain."},{"name":"Dr. de Haro, Dr. Batlle, Subir\u00e0, Dr. L\u00f3pez-Aguilar, Dr. Fern\u00e1ndez, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Gom\u00e0, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Centro Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain."},{"name":"Dr. de Haro, Dr. L\u00f3pez-Aguilar, Dr. Blanch, Ms. Xifra-Porxas, Ms. Santos-Pulp\u00f3n, Ms. Fern\u00e1ndez-Gonzalo, Ms. Estela, Ms. Godoy-Gonz\u00e1lez, Mr. Sarlabous, Mr. Mora, and Mr. Su\u00f1ol are affiliated with Grup d\u2019Investigaci\u00f3 Traslacional del Pacient Cr\u00edtic, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Sabadell, 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S Perktold J. 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