{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:21:53Z","timestamp":1777933313624,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>\n                    Neural stem cells (NSCs) are tissue-specific stem cells with self-renewal potential in brain, and are committed cells of the central nervous system. Recently, some reports have suggested the possibility of the NSCs to differentiate into non-CNS mesodermal derivatives, such as blood cells and skeletal muscle cells. Here we isolated NSCs as neurospheres from a neonatal mouse brain using serum replacement medium, and demonstrated that the stem cell population expressing pluripotent-related genes such as\n                    <jats:italic toggle=\"yes\">Oct-4<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Sox-2<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Nanog<\/jats:italic>\n                    possess multiple differentiation potentials to ectodermal, mesodermal, and endodermal lineages, that is, some neural cells, beating cardiomyocytes, adipocytes, and insulin-producing cells. The results of the present study partly provide further evidence for multiple differentiation properties of NSCs and suggest common characteristics between NSCs and other pluripotent stem cells.\n                  <\/jats:p>","DOI":"10.1089\/scd.2008.0239","type":"journal-article","created":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T16:46:53Z","timestamp":1247590013000},"page":"1433-1440","source":"Crossref","is-referenced-by-count":10,"title":["Potential Existence of Stem Cells With Multiple Differentiation Abilities to Three Different Germ Lineages in Mouse Neurospheres"],"prefix":"10.1177","volume":"18","author":[{"given":"Toshiyuki","family":"Takehara","sequence":"first","affiliation":[{"name":"Graduate School of Biology-Oriented Science and Technology, Kinki University, Nishimitani, Kinokawa, Wakayama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Teramura","sequence":"additional","affiliation":[{"name":"Institute of Advanced Clinical Medicine, Kinki University School of Medicine, Ohno-Higashi, Osaka-Sayama, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Onodera","sequence":"additional","affiliation":[{"name":"Institute of Advanced Clinical Medicine, Kinki University School of Medicine, Ohno-Higashi, Osaka-Sayama, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kishigami","sequence":"additional","affiliation":[{"name":"Graduate School of Biology-Oriented Science and Technology, Kinki University, Nishimitani, Kinokawa, Wakayama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Graduate School of Biology-Oriented Science and Technology, Kinki University, Nishimitani, Kinokawa, Wakayama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Saeki","sequence":"additional","affiliation":[{"name":"Graduate School of Biology-Oriented Science and Technology, Kinki University, Nishimitani, Kinokawa, Wakayama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanji","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Institute of Advanced Clinical Medicine, Kinki University School of Medicine, Ohno-Higashi, Osaka-Sayama, Osaka, Japan."},{"name":"Department of Rehabilitation, Kinki University School of Medicine, Ohno-Higashi, Osaka-Sayama, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Hosoi","sequence":"additional","affiliation":[{"name":"Graduate School of Biology-Oriented Science and Technology, Kinki University, Nishimitani, Kinokawa, Wakayama, 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