{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:16:38Z","timestamp":1791987398384,"version":"4.4.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T00:00:00Z","timestamp":1354752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>\n                    Despite being a histologically dynamic organ, mechanisms coordinating uterine regeneration during the menstrual\/estrous cycle and following parturition are poorly understood. In the current study, we hypothesized that endometrial epithelial tissue regeneration is accomplished, in part, by mesenchymal-to-epithelial transition (MET). To test this hypothesis, fate mapping studies were completed using a double transgenic (Tg) reporter strain,\n                    <jats:italic toggle=\"yes\">Amhr2-Cre<\/jats:italic>\n                    ;\n                    <jats:italic toggle=\"yes\">\n                      Rosa26-Stop\n                      <jats:sup>fl\/fl-EYFP<\/jats:sup>\n                    <\/jats:italic>\n                    (i.e., flox-stop EYFP reporter). EYFP expression was observed in M\u00fcllerian duct mesenchyme-derived stroma and myometrium, but not epithelia in young and peripubertal double Tg female mice. However, mosaic EYFP expression was observed in epithelia of double Tg mice after parturition. To ensure the observed epithelial EYFP expression was not due to leaky\n                    <jats:italic toggle=\"yes\">Amhr2<\/jats:italic>\n                    promoter activity, resulting in aberrant Cre expression, transgenic mice expressing\n                    <jats:italic toggle=\"yes\">LacZ<\/jats:italic>\n                    under the control of the\n                    <jats:italic toggle=\"yes\">Amhr2<\/jats:italic>\n                    promoter (\n                    <jats:italic toggle=\"yes\">Amhr2-LacZ<\/jats:italic>\n                    ) were used to monitor \u03b2-galactosidase (\u03b2-Gal) activity within the uterus. \u03b2-Gal activity was not detected in luminal or glandular epithelia regardless of age, reproductive status, or degree of damage incurred within the uterus. Lastly, a unique population of transitional cells was identified that expressed the epithelial cell marker, pan-cytokeratin, and the stromal cell marker, vimentin. These cells localized predominantly to the regeneration zone in the mesometrial region of the endometrium. These findings suggest a previously unappreciated role for MET in endometrial regeneration and have important implications for proliferative diseases of the endometrium such as endometriosis.\n                  <\/jats:p>","DOI":"10.1089\/scd.2012.0435","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T15:39:38Z","timestamp":1354808378000},"page":"964-974","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":112,"title":["Mesenchymal-to-Epithelial Transition Contributes to Endometrial Regeneration Following Natural and Artificial Decidualization"],"prefix":"10.1177","volume":"22","author":[{"given":"Amanda L.","family":"Patterson","sequence":"first","affiliation":[{"name":"Washington State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson A.","family":"Arango","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Pru","sequence":"additional","affiliation":[{"name":"Washington State University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,12,6]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"National Health Statistics Reports no. 51","author":"Martinez G","year":"2012","unstructured":"Martinez G, , Daniels K, , Chandra A. 2012. Fertility of men and women aged 15\u201344 years in the United States: national survey of family growth, 2006\u20132010. National Health Statistics Reports no. 51. National Center for Health Statistics: Hyattsville, MD."},{"key":"e_1_3_3_3_2","unstructured":"Howlader N Noone AM Krapcho M Neyman N Aminou R Altekruse SF Kosary CL Ruhl J Tatalovich Z Cho H Mariotto A Eisner MP Lewis DR Chen HS Feuer EJ Cronin KA. SEER Cancer Statistics Review 1975-2009 (Vintage 2009 Populations) 2012. National Cancer Institute: Bethesda MD http:\/\/seer.cancer.gov\/csr\/1975_2009_pops09\/"},{"key":"e_1_3_3_4_2","unstructured":"Endometriosis National Institute of Child Health Human Development. 2012. www.nichd.nih.gov\/health\/topics\/endometri\/conditioninfo\/pages\/at-risk.aspx."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-6-37"},{"key":"e_1_3_3_6_2","first-page":"85","volume-title":"Current Topics in Developmental Biology","author":"Spencer TE","year":"2005","unstructured":"Spencer TE, , Hayashi K, , Hu J, , Carpenter KD, , Gerald PS. 2005. Comparative developmental biology of the mammalian uterus. Gerald P. Schatten. Current Topics in Developmental Biology. 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