{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:48:35Z","timestamp":1792705715354,"version":"4.5.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"20","license":[{"start":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T00:00:00Z","timestamp":1400284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>\n                    The objective of this study was to evaluate the safety and efficacy of allogeneic bone marrow mesenchymal stromal\/stem cell transplantation (BM-MSCT) for patients with ursodeoxycholic acid (UDCA)-resistant primary biliary cirrhosis (PBC). Ten patients were enrolled in this trial of BM-MSCT. All patients were permitted to concurrently continue their previous UDCA treatment. The efficacy of BM-MSCT in UDCA-resistant PBC was assessed at various time points throughout the 12-month follow up. No transplantation-related side effects were observed. The life quality of the patients was improved after BM-MSCT as demonstrated by responses to the PBC-40 questionnaire. Serum levels of ALT, AST, \u03b3-GT, and IgM significantly decreased from baseline after BM-MSCT. In addition, the percentage of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells was reduced, while that of CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD25\n                    <jats:sup>+<\/jats:sup>\n                    Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    T cells was increased in peripheral lymphocytic subsets. Serum levels of IL-10 were also elevated. Notably, the optimal therapeutic outcome was acquired in 3 to 6 months and could be maintained for 12 months after BM-MSCT. In conclusion, allogeneic BM-MSCT in UDCA-resistant PBC is safe and appears to be effective.\n                  <\/jats:p>","DOI":"10.1089\/scd.2013.0500","type":"journal-article","created":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T03:07:44Z","timestamp":1400296064000},"page":"2482-2489","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":82,"title":["Allogeneic Bone Marrow Mesenchymal Stem Cell Transplantation in Patients with UDCA-Resistant Primary Biliary Cirrhosis"],"prefix":"10.1177","volume":"23","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"Peking Union Medical College Hospital (PUMCH)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Han","sequence":"additional","affiliation":[{"name":"Peking Union Medical College 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