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Recent studies have indicated that extracellular vesicles, previously referred to as microvesicles or exosomes, have the capacity to change the phenotype of neighboring cells. Extensive work has shown that vesicles derived from either the lung or liver can enter bone marrow cells (this is a prerequisite) and alter their fate toward that of the originating liver and lung tissue. Lung vesicles interacted with bone marrow cells result in the bone marrow cells expressing surfactants A\u2013D, Clara cell protein, and aquaporin-5 mRNA. In a similar vein, liver-derived vesicles induce albumin mRNA in target marrow cells. The vesicles contain protein, mRNA, microRNA, and noncoding RNA and variably some DNA. This genetic package is delivered to cells and alters the phenotype. Further studies have shown that initially the altered phenotype is due to the transfer of mRNA and a transcriptional modulator, but long-term epigenetic changes are induced through transfer of a transcriptional factor, and the mRNA is rapidly degraded in the cell. Studies on the capacity of vesicles to restore injured tissue have been quite informative. Mesenchymal stem cell-derived vesicles are able to reverse the injury to the damaged liver and kidney. Other studies have shown that mesenchymal stem cell-derived vesicles can reverse radiation toxicity of bone marrow stem cells. Extracellular vesicles offer an intriguing strategy for treating a number of diseases characterized by tissue injury.<\/jats:p>","DOI":"10.1089\/scd.2013.0594","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T07:25:27Z","timestamp":1393313127000},"page":"1429-1436","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":74,"title":["Cellular Phenotype and Extracellular Vesicles: Basic and Clinical Considerations"],"prefix":"10.1177","volume":"23","author":[{"given":"Peter J.","family":"Quesenberry","sequence":"first","affiliation":[{"name":"Rhode Island Hospital"},{"name":"Rhode Island Hospital"},{"name":"Rhode Island Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura R.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital"},{"name":"Rhode Island Hospital"},{"name":"Rhode Island Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M.","family":"Aliotta","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Dooner","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy G.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sicheng","family":"Wen","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Camussi","sequence":"additional","affiliation":[{"name":"University of Torino","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,2,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.11.3791"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)48095-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0598-594"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.19.3365"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri855"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(11)70019-6"},{"key":"e_1_3_2_8_2","first-page":"1104","article-title":"A Plasma microRNA signature of acute leniviral infection: biomarkers of CAN disease","volume":"204","author":"Witer KW","year":"2011","unstructured":"Witer KW, , Sarbanes SL, , Liu J, and Clemens JE. 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