{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:09:27Z","timestamp":1791119367120,"version":"4.1.0"},"reference-count":47,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>\n                    Bone and fat cells share a common progenitor, stromal\/mesenchymal stem cells (MSCs), that can differentiate into osteoblasts or adipocytes. Osteogenesis and adipogenesis of MSCs maintain homeostasis under physiological conditions. The disruption of this homeostasis leads to bone-related metabolic diseases. For instance, reduction in bone formation, which is usually accompanied by an increase in bone marrow adipogenesis, occurs with aging, immobility, or osteoporosis. Thus, it is crucial to gain an understanding of how osteogenic and adipogenic lineages of MSCs are regulated. Here, we present evidence that\n                    <jats:italic toggle=\"yes\">let-7<\/jats:italic>\n                    is a positive regulator of bone development. Using gain- and loss-of-function approaches, we demonstrate that\n                    <jats:italic toggle=\"yes\">let-7<\/jats:italic>\n                    markedly promotes osteogenesis and suppresses adipogenesis of MSCs in vitro. Moreover,\n                    <jats:italic toggle=\"yes\">let-7<\/jats:italic>\n                    could promote ectopic bone formation of MSCs in vivo. Subsequent studies further demonstrated that\n                    <jats:italic toggle=\"yes\">let-7<\/jats:italic>\n                    's effects are mediated through the repression of high-mobility group AT-hook 2 (HMGA2) expression. RNAi depletion of HMGA2 could also enhance osteogenesis and repress adipogenesis. Overall, we found a novel role of\n                    <jats:italic toggle=\"yes\">let-7<\/jats:italic>\n                    \/HMGA2 axis in regulating the balance of osteogenesis and adipogenesis of MSCs. Thus,\n                    <jats:italic toggle=\"yes\">let-7<\/jats:italic>\n                    can be used as a novel therapeutic target for disorders that are associated with bone loss and adipocyte accumulation.\n                  <\/jats:p>","DOI":"10.1089\/scd.2013.0600","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T13:56:25Z","timestamp":1394546185000},"page":"1452-1463","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":154,"title":["<i>let-7<\/i>\n                    Enhances Osteogenesis and Bone Formation While Repressing Adipogenesis of Human Stromal\/Mesenchymal Stem Cells by Regulating HMGA2"],"prefix":"10.1177","volume":"23","author":[{"given":"Jianfeng","family":"Wei","sequence":"first","affiliation":[{"name":"School of Basic Medicine Peking Union Medical College","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medicine Peking Union Medical College","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine Peking Union Medical College","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangping","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medicine Peking Union Medical College","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfen","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Basic Medicine Peking Union Medical 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