{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:08:59Z","timestamp":1791112139652,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"23","license":[{"start":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T00:00:00Z","timestamp":1405382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>\n                    The dentin sialophosphoprotein (\n                    <jats:italic toggle=\"yes\">dspp<\/jats:italic>\n                    ) transcript is expressed during tooth development as a DSPP precursor protein, which then undergoes cleavage to form mature dentin sialoprotein (DSP) and phosphophoryn (PP) proteins. Previous studies using DSPP-knockout (KO) mice have reported that these animals have hypomineralized teeth, thin dentin, and a large dental pulp chamber, similar to those from patients with dentinogenesis imperfecta III. However, there is no information about factors that regulate dental pulp stem cell lineage fate, a critical early event in the odontoblast-dentin mineralization scheme. To reveal the role of DSPP in odontoblast lineage differentiation during tooth development, we systematically examined teeth from wild-type (wt) and DSPP-KO C57BL\/6 mice between the ages of postnatal day 1 and 3 months. We found developmental abnormalities not previously reported, such as circular dentin formation within dental pulp cells and altered odontoblast differentiation in DSPP-KO mice, even as early as 1 day after birth. Surprisingly, we also identified chondrocyte-like cells in the dental pulp from KO-mice teeth. Thus, these studies that compare wt and DSPP-KO mice suggest that the expression of DSPP precursor protein is required for normal odontoblast lineage differentiation and that the absence of DSPP allows dental pulp cells to differentiate into chondrocyte-like cells, which could negatively impact pulpal wound healing and tissue regeneration.\n                  <\/jats:p>","DOI":"10.1089\/scd.2014.0066","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T21:58:54Z","timestamp":1405461534000},"page":"2883-2894","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Dentin Sialophosphoprotein: A Regulatory Protein for Dental Pulp Stem Cell Identity and Fate"],"prefix":"10.1177","volume":"23","author":[{"given":"Shiliang","family":"Guo","sequence":"first","affiliation":[{"name":"University of Michigan"},{"name":"Nanjing University Medical Center","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandrich","family":"Lim","sequence":"additional","affiliation":[{"name":"University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Dong","sequence":"additional","affiliation":[{"name":"University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Saunders","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter X.","family":"Ma","sequence":"additional","affiliation":[{"name":"University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia L.","family":"Marcelo","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena H.","family":"Ritchie","sequence":"additional","affiliation":[{"name":"University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,7,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00410"},{"key":"e_1_3_3_3_2","first-page":"382","article-title":"Tooth development","author":"Thesleff I","year":"1991","unstructured":"Thesleff I. 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