{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:14:35Z","timestamp":1789744475290,"version":"4.0.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"24","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n                    Gunn rats bear a mutation within the uridine diphosphate glucuronosyltransferase-1a1 (\n                    <jats:italic toggle=\"yes\">Ugt1a1<\/jats:italic>\n                    ) gene resulting in high serum bilirubin levels as seen in Crigler-Najjar syndrome. In this study, the Gunn rat was used as an animal model for heritable liver dysfunction. Induced mesenchymal stem cells (iMSCs) derived from embryonic stem cells (H1) and induced pluripotent stem cells were transplanted into Gunn rats after partial hepatectomy. The iMSCs engrafted and survived in the liver for up to 2 months. The transplanted iMSCs differentiated into functional hepatocytes as evidenced by partially suppressed hyperbilirubinemia and expression of multiple human-specific hepatocyte markers such as albumin, hepatocyte nuclear factor 4\u03b1,\n                    <jats:italic toggle=\"yes\">UGT1A1<\/jats:italic>\n                    , cytokeratin 18, bile salt export pump, multidrug resistance protein 2, Na\/taurocholate-cotransporting polypeptide, and \u03b1-fetoprotein. These findings imply that transplanted human iMSCs can contribute to liver regeneration in vivo and thus represent a promising tool for the treatment of inherited liver diseases.\n                  <\/jats:p>","DOI":"10.1089\/scd.2018.0010","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T09:49:25Z","timestamp":1538560165000},"page":"1702-1714","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Transplanted Human Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Support Liver Regeneration in Gunn Rats"],"prefix":"10.1177","volume":"27","author":[{"given":"Lucas-Sebastian","family":"Spitzhorn","sequence":"first","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Kordes","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Megges","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Sawitza","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"G\u00f6tze","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Reichert","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Schulze-Matz","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Graffmann","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Bohndorf","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasco","family":"Wruck","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Philipp","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diran","family":"Herebian","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ertan","family":"Mayatepek","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard O.C.","family":"Oreffo","sequence":"additional","affiliation":[{"name":"University of Southampton","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"H\u00e4ussinger","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Adjaye","sequence":"additional","affiliation":[{"name":"Heinrich Heine University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"169","article-title":"Congenital familial nonhemolytic jaundice with kernicterus","volume":"10","author":"Crigler JF","year":"1952","unstructured":"Crigler JFJr., and Najjar VA. 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