{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:57:59Z","timestamp":1792292279074,"version":"4.4.0"},"reference-count":59,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n                    Degenerative joint disease is one of the main causes of equine early retirement from pleasure riding or a performance career. The disease is initially triggered by an abnormal loading of normal cartilage or a normal loading of abnormal cartilage. This primary insult is accompanied with joint inflammation, which leads to further progressive degeneration of the articular cartilage and changes in the surrounding tissues. Therefore, in search for an effective treatment, 75 adult horses with early signs of degenerative fetlock joint disease were enrolled in a randomized, multicenter, double-blinded, and placebo-controlled study. Fifty animals were injected intra-articularly with the investigational veterinary product (IVP) consisting of allogeneic chondrogenic induced mesenchymal stem cells (ciMSCs) with equine allogeneic plasma, and 25 horses were injected with 0.9% NaCl (saline) control product. From week 3 to 18 after treatment, lameness scores (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.001), flexion test responses (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.034), and joint effusion scores (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.001) were remarkably superior in IVP-treated horses. Besides nasal discharge in both treatment groups, no adverse events were observed during the entire study period. On long-term follow-up (1 year), significantly more investigational product-treated horses were working at training level or were returned to their previous level of work (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.001).\n                  <\/jats:p>","DOI":"10.1089\/scd.2018.0061","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T05:58:16Z","timestamp":1547013496000},"page":"410-422","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":58,"title":["Equine Allogeneic Chondrogenic Induced Mesenchymal Stem Cells Are an Effective Treatment for Degenerative Joint Disease in Horses"],"prefix":"10.1177","volume":"28","author":[{"given":"Sarah Y.","family":"Broeckx","sequence":"first","affiliation":[{"name":"Global Stem cell Technology NV, Anacura Group, Evergem, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Seys","sequence":"additional","affiliation":[{"name":"Equine Veterinary Practice Dr Suls, SP Weert, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Suls","sequence":"additional","affiliation":[{"name":"Equine Veterinary Practice Dr Suls, SP Weert, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Equine Veterinary Service Adriaensen-Vandenberghe, Waasmunster, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Mari\u00ebn","sequence":"additional","affiliation":[{"name":"Equitom Equine Hospital, Meldert, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Adriaensen","sequence":"additional","affiliation":[{"name":"Equine Veterinary Service Adriaensen-Vandenberghe, Waasmunster, Belgium."},{"name":"Equitom Equine Hospital, Meldert, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Declercq","sequence":"additional","affiliation":[{"name":"Veterinary Practitioner, Oudenaarde, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lore","family":"Van Hecke","sequence":"additional","affiliation":[{"name":"Global Stem cell Technology NV, Anacura Group, Evergem, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Braun","sequence":"additional","affiliation":[{"name":"Klifovet AG, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Hellmann","sequence":"additional","affiliation":[{"name":"Klifovet AG, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Spaas","sequence":"additional","affiliation":[{"name":"Global Stem cell Technology NV, Anacura Group, Evergem, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,3,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.111.2000132"},{"key":"e_1_3_3_3_2","article-title":"From Arthroscopy to gene therapy\u201430 years of looking into joints","author":"McIlwraith CW","year":"2005","unstructured":"McIlwraith CW. 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