{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:29:00Z","timestamp":1777933740652,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    Interleukin (IL)-10-producing type 1 regulatory T (Tr1) cells, which are Foxp3\n                    <jats:sup>\u2212<\/jats:sup>\n                    memory T lymphocytes, play important roles in peripheral immune tolerance. We investigated whether Tr1 cells exert immunoregulatory effects in a mouse model of acute graft-versus-host disease (GVHD). Mouse CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells were induced to differentiate in vitro into Tr1 cells using vitamin D3 and dexamethasone, and these donor-derived Tr1 cells were infused on the day of bone marrow transplantation. The Tr1 cell-transferred group showed less weight-loss and a twofold higher survival rate than the GVHD group, together with markedly decreased histopathologic grades. It was associated with the expansion of CD4\n                    <jats:sup>+<\/jats:sup>\n                    IL-4\n                    <jats:sup>+<\/jats:sup>\n                    type 2 T-helper (Th2) cells and CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD25\n                    <jats:sup>+<\/jats:sup>\n                    Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T (Treg) cells. Furthermore, Tr1 cells decreased the numbers of CD4\n                    <jats:sup>+<\/jats:sup>\n                    interferon-\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    Th1 and CD4\n                    <jats:sup>+<\/jats:sup>\n                    IL-17\n                    <jats:sup>+<\/jats:sup>\n                    Th17 cells. Recipient mice harbored some Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Tregs due to adoptive transfer of Tr1 cells, together with the upregulated expression of costimulatory molecules, including cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and inducible T-cell costimulator (ICOS); however, the Treg cells did not show the plasticity. Therefore, adoptive Tr1 cell therapy may be effective against manifestations of GVHD, exert immunomodulatory effects in a manner dependent on CTLA-4 and ICOS, and induce differentiation of the transferred Tr1 cells into Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Treg cells.\n                  <\/jats:p>","DOI":"10.1089\/scd.2018.0113","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T08:07:15Z","timestamp":1541059635000},"page":"129-140","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Enhancement of Graft-Versus-Host Disease Control Efficacy by Adoptive Transfer of Type 1 Regulatory T Cells in Bone Marrow Transplant Model"],"prefix":"10.1177","volume":"28","author":[{"given":"Young-Woo","family":"Jeon","sequence":"first","affiliation":[{"name":"Institute for Translational Research and Molecular Imaging, College of Medicine, The Catholic University of Korea, Seoul, Korea."},{"name":"Laboratory of Immune Regulation, Convergent Research Consortium for Immunologic Disease, College of Medicine, The Catholic University of Korea, Seoul, Korea."},{"name":"Lymphoma-Myeloma Center, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Yeon","family":"Lim","sequence":"additional","affiliation":[{"name":"Institute for Translational Research and Molecular Imaging, College of Medicine, The Catholic University of Korea, Seoul, Korea."},{"name":"Laboratory of Immune Regulation, Convergent Research Consortium for Immunologic Disease, College of Medicine, The Catholic University of Korea, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keon-Il","family":"Im","sequence":"additional","affiliation":[{"name":"Institute for Translational Research and Molecular Imaging, College of Medicine, The Catholic University of Korea, Seoul, Korea."},{"name":"Laboratory of Immune Regulation, Convergent Research Consortium for Immunologic Disease, College of Medicine, The Catholic University of Korea, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayoun","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute for Translational Research and Molecular Imaging, College of Medicine, The Catholic University of Korea, Seoul, Korea."},{"name":"Laboratory of Immune Regulation, Convergent Research Consortium for Immunologic Disease, College of Medicine, The Catholic University of Korea, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Sun","family":"Nam","sequence":"additional","affiliation":[{"name":"Institute for Translational Research and Molecular Imaging, College of Medicine, The Catholic University of Korea, Seoul, Korea."},{"name":"Laboratory of Immune Regulation, Convergent 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Korea."},{"name":"Lymphoma-Myeloma Center, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 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