{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:16:27Z","timestamp":1791400587555,"version":"4.3.3"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>\n                    Bronchopulmonary dysplasia (BPD), the main complication of extreme prematurity, has lifelong consequences for lung health. Mesenchymal stromal cells (MSCs) prevent lung injury in experimental BPD in newborn rodents when given in the immediate neonatal period. Whether MSC therapy can restore normal lung growth after established lung injury in adulthood is clinically relevant, but currently unknown. Experimental BPD was achieved by exposing newborn rats to 95% O\n                    <jats:sub>2<\/jats:sub>\n                    from postnatal days 4\u201314. Human umbilical cord-derived MSCs were intratracheally administered to rats (1\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    cells\/kg body weight) as a single dose at 3 or 6 months of age followed by assessment at 5 or 8 months of age, respectively. Lung alveolar structure and vessel density were histologically analyzed. O\n                    <jats:sub>2<\/jats:sub>\n                    -exposed rats exhibited persistent lung injury characterized by arrested alveolar growth with airspace enlargement and a lower vessel density at both 5 and 8 months of age compared with controls. Single-dose MSC treatment at 3 months partially attenuated O\n                    <jats:sub>2<\/jats:sub>\n                    -induced alveolar injury and restored vessel density at 5 months. Treatment with a single dose at 6 months did not attenuate alveolar injury or vessel density at 8 months. However, treatment with multiple MSC doses at 6, 6.5, 7, and 7.5 months significantly attenuated alveolar injury and improved vessel density at 8 months of age. Treatment of the adult BPD lung with MSCs has the potential to improve lung injury if administered in multiple doses or at an early stage of adulthood.\n                  <\/jats:p>","DOI":"10.1089\/scd.2019.0116","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:25:22Z","timestamp":1578615922000},"page":"364-371","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia"],"prefix":"10.1177","volume":"29","author":[{"given":"Megan","family":"O'Reilly","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton, Canada."},{"name":"Women and Children's Health Research Institute, and University of Alberta, Edmonton, Canada."},{"name":"Department of Physiology, University of Alberta, Edmonton, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius A.","family":"M\u00f6bius","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton, Canada."},{"name":"Women and Children's Health Research Institute, and University of Alberta, Edmonton, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arul","family":"Vadivel","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Ottawa Hospital Research Institute, Sinclair Center for Regenerative Medicine, Ottawa, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton, Canada."},{"name":"Women and Children's Health Research Institute, and University of Alberta, Edmonton, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton, Canada."},{"name":"Women and Children's Health Research Institute, and University of Alberta, Edmonton, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Eaton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton, Canada."},{"name":"Women and Children's Health Research Institute, and University of Alberta, Edmonton, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Greer","sequence":"additional","affiliation":[{"name":"Women and Children's Health Research Institute, and University of Alberta, Edmonton, Canada."},{"name":"Department of Physiology, University of Alberta, Edmonton, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Th\u00e9baud","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Ottawa Hospital Research Institute, Sinclair Center for Regenerative Medicine, Ottawa, Canada."},{"name":"Children's Hospital of Eastern Ontario, Ottawa, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3283423e6b"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01959.x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02404.x"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00127107"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2522"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00185511"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200705-701OC"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2651"},{"key":"e_1_3_4_10_2","first-page":"10","article-title":"Early pulmonary vascular disease in young adults born preterm","author":"Goss KN","year":"2018","unstructured":"Goss KN, , Beshish AG, , Barton GP, , Haraldsdottir K, , Levin TS, , Tetri LH, , Battiola TJ, , Mulchrone AM, , Pegelow DF, et al. 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