{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:29:54Z","timestamp":1777933794662,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n                    Many persons with diabetes mellitus have limb ischemia, which is a major clinical problem. A subset of human monocytes that expresses TIE-2 may enhance neovascularization. We performed 179 phlebotomies on 142 patients (or donors), including 61 patients\/donors without diabetes or ischemia (controls), 39 diabetic nonischemic patients (controls), and 42 diabetic patients with severe limb ischemia requiring amputation. We compared these groups for the presence of TIE-2-positive proangiogenic monocytes. The proportion of proangiogenic monocytes in the venous blood (on hospital admission) was significantly increased in diabetic patients without ischemia (9.22%\u2009\u00b1\u20091.19%), compared to controls (6.53%\u2009\u00b1\u20090.58%) or ischemic diabetic patients (5.44%\u2009\u00b1\u20090.56%) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.05). In this pilot evaluation, we succeeded in extracting potential proangiogenic TIE-2 monocytes from the blood of diabetic patients without ischemia, but less in patients with ischemia. The implications for therapeutic neoangiogenesis require further studies.\n                  <\/jats:p>","DOI":"10.1089\/scd.2019.0266","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T02:10:24Z","timestamp":1589854224000},"page":"911-918","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Characterization of Proangiogenic Monocytes from Blood in Patients with Chronic Ischemic Diabetic Foot Ulcers and Controls"],"prefix":"10.1177","volume":"29","author":[{"given":"Ilker","family":"U\u00e7kay","sequence":"first","affiliation":[{"name":"Service of Infectious Diseases, Department of Specialities in Medicine, University of Geneva, Geneva, Switzerland."},{"name":"Infectiology, Balgrist University Hospital, Zurich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat A.","family":"Imhof","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Kressmann","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases, Department of Specialities in Medicine, University of Geneva, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lew","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases, Department of Specialities in Medicine, University of Geneva, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin A.","family":"Lipsky","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases, Department of Specialities in Medicine, University of Geneva, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adama","family":"Sidibe","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland."},{"name":"Department of Cell Physiology and Metabolism, Medical Faculty, University of Geneva, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180302145754"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.08.033"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2009.0872"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02610-0"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132557"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-053504"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0012"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201302752"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.51"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3181"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.7405"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4RI0818-311R"},{"key":"e_1_3_5_14_2","first-page":"10","article-title":"Simultaneous study of the recruitment of monocyte subpopulations under flow in vitro","author":"Ropraz P","year":"2018","unstructured":"Ropraz P, , Imhof BA, , Matthes T, , Wehrle-Haller B, and Sidibe A. (2018). Simultaneous study of the recruitment of monocyte subpopulations under flow in vitro. J Vis Exp, DOI: 10.3791\/58509.","journal-title":"J Vis Exp"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000025690"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1051"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-078733"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-675470"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-651331"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25102"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.01.015"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00393-X"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwi050"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.08.004"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-295246"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06925.x"},{"key":"e_1_3_5_27_2","first-page":"452","article-title":"Regenerative secretoma of adipose-derived stem cells from ischemic patients","volume":"9","author":"U\u00e7kay I","year":"2019","unstructured":"U\u00e7kay I, , Baqui\u00e9 M, , Mosser S, , Herv\u00e9 MP, , Bruyere-Cerdan P, , Roux-Lombard P, , Modoux C, , Kocjancic-Curty L, , R\u00fcegg E, et al. (2019). Regenerative secretoma of adipose-derived stem cells from ischemic patients. 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