{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:29:54Z","timestamp":1777933794430,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n                    Avascular necrosis (AVN) is a severe complication of immunosuppressant therapy or chemotherapy. A beneficial AVN therapy with core decompression (CD) and intraosseous infusion of mesenchymal stromal cells (MSCs) has been described in adult patients, but there are only few data on MSC applications in pediatric and young adult patients (PYAP). Between 2006 and 2015, 14 AVN lesions of 10 PYAP (6 females) with a median age of 16.9 years (range 8.5\u201325.8 years) received CD and intraosseous application of autologous MSCs. Data of these patients were analyzed regarding efficacy, safety, and feasibility of this procedure as AVN therapy and compared with a control group of 13 AVN lesions of 11 PYAP (5 females) with a median age of 17.9 years (range 13.5\u201327.5 years) who received CD only. During the follow-up analysis [MSC group: median 3.1 (1.6\u20135.8) years after CD; CD group: median 2.0 (1.5\u20138.5) years after CD], relative lesion sizes (as assessed by magnetic resonance imaging) compared with the initial lesion volume, were significantly lower (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.05) in the MSC group (volume reduction to a median of 18.5%) when compared with the CD group (58.0%). One lesion in the MSC group comprised a complete remission. Size progression was not observed in either group. Clinical improvement (pain, mobility) was not significantly different between the two groups. None of the patients experienced treatment-related adverse effects. CD and additional MSC application was regarded safe, effective, feasible, and superior in reducing the lesion size when compared with CD only. Prospective, randomized clinical trials are needed to further evaluate these findings.\n                  <\/jats:p>","DOI":"10.1089\/scd.2020.0019","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T04:50:08Z","timestamp":1587012608000},"page":"811-822","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Longtime Outcome After Intraosseous Application of Autologous Mesenchymal Stromal Cells in Pediatric Patients and Young Adults with Avascular Necrosis After Steroid or Chemotherapy"],"prefix":"10.1177","volume":"29","author":[{"given":"Michaela","family":"D\u00f6ring","sequence":"first","affiliation":[{"name":"Department I\u2014General Pediatrics, Hematology and Oncology, University Hospital Tuebingen\u2014Children's Hospital Tuebingen, Tuebingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Kluba","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, St\u00e4dtisches Klinikum Dresden, Dresden, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin Melanie","family":"Cabanillas Stanchi","sequence":"additional","affiliation":[{"name":"Department I\u2014General Pediatrics, Hematology and Oncology, University Hospital Tuebingen\u2014Children's Hospital Tuebingen, Tuebingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kahle","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, University Hospital Tuebingen, Tuebingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Lenglinger","sequence":"additional","affiliation":[{"name":"Department I\u2014General Pediatrics, Hematology and Oncology, University Hospital Tuebingen\u2014Children's Hospital Tuebingen, Tuebingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Tsiflikas","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Tuebingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Treuner","sequence":"additional","affiliation":[{"name":"Department I\u2014General Pediatrics, Hematology and Oncology, University Hospital Tuebingen\u2014Children's Hospital Tuebingen, Tuebingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Vaegler","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Campus Berlin Buch, Experimental and Clinical Research Center, Zellkulturlabor f\u00fcr Klinische Pr\u00fcfung ZKP, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Mezger","sequence":"additional","affiliation":[{"name":"Department I\u2014General Pediatrics, Hematology and Oncology, University Hospital Tuebingen\u2014Children's Hospital Tuebingen, Tuebingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Erbacher","sequence":"additional","affiliation":[{"name":"Department I\u2014General Pediatrics, Hematology and Oncology, University Hospital Tuebingen\u2014Children's Hospital Tuebingen, Tuebingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schumm","sequence":"additional","affiliation":[{"name":"Department I\u2014General Pediatrics, Hematology and Oncology, University Hospital Tuebingen\u2014Children's Hospital Tuebingen, Tuebingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Lang","sequence":"additional","affiliation":[{"name":"Department I\u2014General Pediatrics, Hematology and Oncology, University Hospital Tuebingen\u2014Children's Hospital Tuebingen, Tuebingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupert","family":"Handgretinger","sequence":"additional","affiliation":[{"name":"Department I\u2014General Pediatrics, Hematology and Oncology, University Hospital Tuebingen\u2014Children's Hospital Tuebingen, Tuebingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department I\u2014General Pediatrics, Hematology and Oncology, University Hospital Tuebingen\u2014Children's Hospital Tuebingen, Tuebingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.8.3247.3247"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20244"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4811-9_66"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650111122"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704360"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.095562"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25553"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-123885"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.11.020"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.04.1598"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.04.1597"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-200005000-00012"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-45495"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.33724b"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199901)32:1<11::AID-MPO4>3.0.CO;2-F"},{"key":"e_1_3_3_17_2","first-page":"2994","article-title":"Bone marrow magnetic resonance studies in childhood leukemia","volume":"60","author":"Pieters R","year":"1987","unstructured":"Pieters R, , van Brenk AI, , Veerman AJ, , van Amerongen AH, , van Zanten TE, and Golding RP. (1987). Bone marrow magnetic resonance studies in childhood leukemia. Evaluation of osteonecrosis. Cancer, 60:2994\u20133000.","journal-title":"Evaluation of osteonecrosis. Cancer"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/17453670610013574"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701374"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B7.16289"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01265.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02932"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2004.11.007"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200406000-00006"},{"key":"e_1_3_3_25_2","first-page":"213","article-title":"Core decompression and nonvascularized bone grafting for the treatment of early stage osteonecrosis of the femoral head","volume":"56","author":"Mont MA","year":"2007","unstructured":"Mont MA, , Marulanda GA, , Seyler TM, , Plate JF, and Delanois RE. (2007). Core decompression and nonvascularized bone grafting for the treatment of early stage osteonecrosis of the femoral head. Instr Course Lect, 56:213\u2013220.","journal-title":"Instr Course Lect"},{"key":"e_1_3_3_26_2","first-page":"3","article-title":"Treatment of osteonecrosis of the femoral head by percutaneous decompression and autologous bone marrow mononuclear cell infusion","volume":"9","author":"Yan ZQ","year":"2006","unstructured":"Yan ZQ, , Chen YS, , Li WJ, , Yang Y, , Huo JZ, , Chen ZR, , Shi JH, and Ge JB. (2006). Treatment of osteonecrosis of the femoral head by percutaneous decompression and autologous bone marrow mononuclear cell infusion. Chin J Traumatol, 9:3\u20137.","journal-title":"Chin J Traumatol"},{"key":"e_1_3_3_27_2","first-page":"187","article-title":"Core decompression and conservative treatment for avascular necrosis of the femoral head: a meta-analysis","volume":"29","author":"Castro FP","year":"2000","unstructured":"Castro FPJr., , and Barrack RL. (2000). Core decompression and conservative treatment for avascular necrosis of the femoral head: a meta-analysis. Am J Orthop (Belle Mead NJ), 29:187\u2013194.","journal-title":"Am J Orthop (Belle Mead NJ)"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0036-y"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v2.i2.34"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092526"},{"issue":"3","key":"e_1_3_3_31_2","first-page":"167","article-title":"Use of genetically engineered bone-marrow stem cells to treat femoral defects: an experimental study","author":"Cui Q","year":"2006","unstructured":"Cui Q, , Xiao Z, , Li X, , Saleh KJ, and Balian G. (2006). Use of genetically engineered bone-marrow stem cells to treat femoral defects: an experimental study. J Bone Joint Surg Am 88, (Suppl. 3)::167\u2013172.","journal-title":"J Bone Joint Surg Am 88"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-008-0023-6"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31770"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v029a02"},{"key":"e_1_3_3_35_2","first-page":"739","article-title":"[Treatment of early avascular necrosis of femoral head by core decompression combined with autologous bone marrow mesenchymal stem cells transplantation]","volume":"24","author":"Chang T","year":"2010","unstructured":"Chang T, , Tang K, , Tao X, , Cao H, , Li H, , Chen Q, , Chen L, , Zhou J, , Zhou B, and Xu J. (2010). [Treatment of early avascular necrosis of femoral head by core decompression combined with autologous bone marrow mesenchymal stem cells transplantation]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 24:739\u2013743 (Article in Chinese).","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-296"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2012\/15\/75"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.11.002"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.217"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2009.09.004"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e3181a5ec1f"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.67B1.3155745"},{"key":"e_1_3_3_43_2","first-page":"18","article-title":"A new international classification of osteonecrosis of the ARCO committee on terminology and classification","volume":"66","author":"Gardeniers JW","year":"1992","unstructured":"Gardeniers JW. (1992). A new international classification of osteonecrosis of the ARCO committee on terminology and classification. J Jpn Orthop Assoc, 66:18\u201320.","journal-title":"J Jpn Orthop Assoc"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.217.1.r00oc22213"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2014.04.002"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2015.1077418"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2016(02)10"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6136205"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100160202"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0105-2"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2011.68"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/6529"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.5.1227"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-012-0218-1"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.132252399"}],"container-title":["Stem Cells and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/scd.2020.0019","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/scd.2020.0019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/scd.2020.0019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:59:19Z","timestamp":1777687159000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/scd.2020.0019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,26]]},"references-count":54,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1089\/scd.2020.0019"],"URL":"https:\/\/doi.org\/10.1089\/scd.2020.0019","relation":{},"ISSN":["1547-3287","1557-8534"],"issn-type":[{"value":"1547-3287","type":"print"},{"value":"1557-8534","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,26]]}}}