{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:14:41Z","timestamp":1787807681314,"version":"build-2784847793"},"reference-count":45,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n                    Taste bud cells are specialized epithelial cells that undergo continuous turnover, and thus require active progenitors for their renewal and an intact taste function. Our previous studies suggested that a population of taste bud cells originates from outside of the surrounding tongue epithelium\u2014previously regarded sole source of taste bud progenitors. In this study, we demonstrated that\n                    <jats:italic toggle=\"yes\">SOX10<\/jats:italic>\n                    (SRY-related HMG-box gene 10)-expressing cells, known to be in the migrating neural crest, were also distributed in taste bud-surrounding tissue compartments under the tongue epithelium, that is, the connective tissue core of taste papillae and von Ebner's glands. By lineage tracing of\n                    <jats:italic toggle=\"yes\">SOX10<\/jats:italic>\n                    -expressing cells using\n                    <jats:italic toggle=\"yes\">SOX10-Cre<\/jats:italic>\n                    , a\n                    <jats:italic toggle=\"yes\">Cre<\/jats:italic>\n                    model driven by the endogenous\n                    <jats:italic toggle=\"yes\">SOX10<\/jats:italic>\n                    promoter, crossing with a\n                    <jats:italic toggle=\"yes\">Cre<\/jats:italic>\n                    reporter line R26-tdTomato (tdT), we found\n                    <jats:italic toggle=\"yes\">SOX10-Cre<\/jats:italic>\n                    -labeled tdT\n                    <jats:sup>+<\/jats:sup>\n                    cells within taste buds in all three types of taste papillae (fungiform, circumvallate, and foliate) as well as in the soft palate in postnatal mice. The tdT\n                    <jats:sup>+<\/jats:sup>\n                    taste bud cells were progressively more abundant along the developmental stages, from virtually zero at birth to over 35% in adults. Most of tdT\n                    <jats:sup>+<\/jats:sup>\n                    taste bud cells had a low intensity of immunosignals of Keratin 8 (a widely used taste bud cell marker). In circumvallate taste buds, tdT signals were co-localized principally with a type III taste bud cell marker, less so with type I and II cell makers. Together, our data demonstrate a novel progenitor source for taste buds of postnatal mice\u2014\n                    <jats:italic toggle=\"yes\">SOX10<\/jats:italic>\n                    -\n                    <jats:italic toggle=\"yes\">Cre-<\/jats:italic>\n                    labeled cells in the connective tissue core and\/or von Ebner's glands.\n                  <\/jats:p>","DOI":"10.1089\/scd.2020.0022","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T03:41:51Z","timestamp":1582688511000},"page":"638-647","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>SOX10<\/i>\n                    -\n                    <i>Cre<\/i>\n                    -Labeled Cells Under the Tongue Epithelium Serve as Progenitors for Taste Bud Cells That Are Mainly Type III and Keratin 8-Low"],"prefix":"10.1177","volume":"29","author":[{"given":"Wenxin","family":"Yu","sequence":"first","affiliation":[{"name":"Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Ishan","sequence":"additional","affiliation":[{"name":"Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[{"name":"Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Stice","sequence":"additional","affiliation":[{"name":"Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.27.2.263"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.2307\/3572749"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.05.061"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-11-72"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053399"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-11-129"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.6.1916"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0611"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07184.x"},{"key":"e_1_3_5_11_2","first-page":"107","article-title":"Taste bud regeneration and the search for taste progenitor cells","volume":"148","author":"Miura H","year":"2010","unstructured":"Miura H, and Barlow LA. 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