{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:07:12Z","timestamp":1781176032726,"version":"3.54.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"15","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n                    Previously, we demonstrated the therapeutic effects of human umbilical cord mesenchymal stromal cells (hUC-MSCs) in severe coronavirus disease 2019 (COVID-19) patients. In this 3-month follow-up study, we examined discharged patients who had received hUC-MSC therapy to assess the safety of this therapy and the health-related quality of life (HRQL) of these patients. The follow-up cohort consisted of 28 discharged severe COVID-19 patients who received either the standard treatment (the control group) or the standard treatment plus hUC-MSC therapy. We examined liver function, kidney function, pulmonary function, coagulation, tumor markers, and vision. We also conducted electrocardiography (ECG) analysis, let the patients answer the St. George's Respiratory Questionnaire (SGRQ), and performed computed tomography (CT) imaging for assessing the lung changes. No obvious adverse effects were observed in the hUC-MSC group after 3 months. Measurements of blood routine index, C-reactive protein and procalcitonin, liver and kidney function, coagulation, ECG, tumor markers, and vision were almost within the normal ranges in both the treatment and control groups. Forced expiratory volumes in 1\u2009s (FEV1) (% of predicted) were 71.88%\u2009\u00b1\u20098.46% and 59.45%\u2009\u00b1\u200927.45% in the hUC-MSC and control groups (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.01), respectively, and FEV1\/forced vital capacity (FEV1\/FVC) ratios were 79.95%\u2009\u00b1\u20098.00% and 58.97%\u2009\u00b1\u200919.16% in the hUC-MSC and control groups, respectively (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.05). SGRQ scores were lower in the hUC-MSC group than in the control group (15.25\u2009\u00b1\u20093.69 vs. 31.9\u2009\u00b1\u20098.78,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.05). The rate of wheezing in the hUC-MSC group was also significantly lower than that in the control group (37.5% vs. 75%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.05). There were no significant differences in CT scores between the two groups (0.60\u2009\u00b1\u20090.88 vs. 1.00\u2009\u00b1\u20091.31,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.917). Overall, the intravenous transplantation of hUC-MSCs accelerated partial pulmonary function recovery and improved HRQL, indicating relative safety and preliminary efficacy of this treatment for patients with severe COVID-19.\n                  <\/jats:p>","DOI":"10.1089\/scd.2021.0015","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T01:28:22Z","timestamp":1622165302000},"page":"773-781","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Human Umbilical Cord Mesenchymal Stromal Cell Treatment of Severe COVID-19 Patients: A 3-Month Follow-Up Study Following Hospital Discharge"],"prefix":"10.1177","volume":"30","author":[{"given":"Ganzhu","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingrong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Huangshi Hospital of Traditional Chinese Medicine, Huangshi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningfei","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Huangshi Hospital of Traditional Chinese Medicine, Huangshi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changming","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Cell Tech Medical Research Institute, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyou","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Huangshi Hospital of Traditional Chinese Medicine, Huangshi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2001737"},{"key":"e_1_3_4_5_2","unstructured":"WHO Coronavirus Disease (COVID-19) Dashboard Data last updated: June 16 2021 CET. 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