{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:10:23Z","timestamp":1790878223431,"version":"4.1.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"24","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>\n                    Osteoporosis is an age-related bone disease, characterized by rapid boneloss, decreased bone mineral density (BMD), and consequent risk of fractures. The most prevalent form of clinically significant osteoporosis involves various inflammatory conditions, especially age-dependent osteoporosis and postmenopausal osteoporosis. Tumor necrosis factor-\u03b1 (TNF-\u03b1), a pro-inflammatory cytokine, plays a critical role in the development of inflammatory, which also plays an important role in bone formation and bone loss during osteoporosis. In this report, we examined the effect of TNF-\u03b1 on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and its modulation by resveratrol (Res). We found that TNF-\u03b1 can upregulate inflammatory cytokines,\n                    <jats:italic toggle=\"yes\">Il-6<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Mmp-9,<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Il-1\u03b2<\/jats:italic>\n                    , and establish an inflammatory environment. High inflammatory cytokine expression significantly inhibited osteogenic differentiation of BMSCs by overactivating upstream Hippo kinases and decreasing the nuclear Yes-associated protein (YAP) signals. With Res treatment, decreasing inflammatory cytokine expression normalized Hippo\/YAP signaling and effectively rescued YAP-mediated osteogenesis. Thus, through these studies, we present a mechanism by which TNF-\u03b1 can affect BMSCs osteogenesis through modulation of Hippo\/YAP signaling.\n                  <\/jats:p>","DOI":"10.1089\/scd.2021.0195","type":"journal-article","created":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T01:27:31Z","timestamp":1633138051000},"page":"1202-1214","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Resveratrol Reverses Osteogenic Decline of Bone Marrow Mesenchymal Stem Cells Via Upregulation of YAP Expression in Inflammatory Environment"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8193-7054","authenticated-orcid":false,"given":"Zihan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Gu","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Mao","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Department, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Department, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S54614"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1513724"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jmwh.12954"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01622200"},{"key":"e_1_3_3_6_2","first-page":"235","article-title":"Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF)","volume":"104","author":"Kanis JA","year":"2019","unstructured":"Kanis JA, , Cooper C, , Rizzoli R, and Reginster JY; Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF). 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