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Although surgical intervention is the common remedy for severe cases, it comes with drawbacks, including infection, bleeding, and risk of damage to the cervix and adjacent tissues. Adipose-derived mesenchymal stromal cells (ASCs) are at the focus of modern medicine, as key modulators of tissue homeostasis, inflammation, and tissue repair, rendering them prime candidate agents for tissue regeneration and cell-based therapies. In this study, EPs were isolated from patients admitted to the OB\/GYN department at the Galilee Medical Center and extracted fibroblasts (endometrial polyp fibroblasts, EPFs) were isolated and characterized. ASCs were isolated from healthy patients. The effect of EPF- and ASC-conditioned media (CM) on polyp-derived fibroblasts was evaluated, in both 2D and 3D assays, as well as on the expression of matrix-related gene expression. Herein, EPFs exposed to ASC-CM exhibited reduced migration, invasion, contraction of hydrogels, and extracellular matrix deposition, compared with those exposed to EPF-CM. Altogether, this study suggests that ASCs may have a modulating effect on fibroblasts involved in forming EPs and may serve as the basis for conservative treatment strategies aimed at treating severe cases of EPs.<\/jats:p>","DOI":"10.1089\/scd.2021.0273","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T11:08:44Z","timestamp":1650366524000},"page":"311-321","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Modulatory Effect of Adipose-Derived Stem Cells on Endometrial Polyp Fibroblasts"],"prefix":"10.1177","volume":"31","author":[{"given":"Reema","family":"Fadoul","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Galilee College of Dental Sciences, Galilee Medical Center, Nahariya, Israel."},{"name":"The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tharwat","family":"Haj Khalil","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Galilee College of Dental Sciences, Galilee Medical Center, Nahariya, Israel."},{"name":"The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-9988","authenticated-orcid":false,"given":"Idan","family":"Redenski","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Galilee College of Dental Sciences, Galilee Medical Center, Nahariya, Israel."},{"name":"The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Oren","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Galilee College of Dental Sciences, Galilee Medical Center, Nahariya, Israel."},{"name":"The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asaf","family":"Zigron","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Galilee College of Dental Sciences, Galilee Medical Center, Nahariya, Israel."},{"name":"The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avishalom","family":"Sharon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Galilee Medical Center, Nahariya, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amiel A.","family":"Dror","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Galilee College of Dental Sciences, Galilee Medical Center, Nahariya, Israel."},{"name":"Department of Otolaryngology-Head and Neck Surgery, Galilee Medical Center, Nahariya, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizied","family":"Falah","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Galilee College of Dental Sciences, Galilee Medical Center, Nahariya, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Srouji","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Galilee College of Dental Sciences, Galilee Medical Center, Nahariya, Israel."},{"name":"The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/518398"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144857"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050312119848247"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.5468\/KJOG.2011.54.12.836"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198306000-00007"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2003.00163.x"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2011.05.018"},{"key":"e_1_3_4_9_2","first-page":"168","article-title":"Pregnancy rates after hysteroscopic polypectomy and myomectomy in infertile women","volume":"94","author":"Varasteh NN","year":"1999","unstructured":"Varasteh NN, , Neuwirth RS, , Levin B, and Keltz MD. 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