{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T23:44:46Z","timestamp":1783813486888,"version":"3.55.0"},"reference-count":125,"publisher":"SAGE Publications","issue":"19-20","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Adipose-derived stromal cells (ADSCs) have well-established regenerative and immunomodulatory properties. For such reasons, ADSCs are currently under investigation for their use in the setting of both regenerative medicine and autoimmune diseases. As per dermatological disorders, mesenchymal stromal cell (MSC)-based strategies represent potential therapeutic tools not only for chronic ulcers and wound healing, but also for immune-mediated dermatoses. However, a growing body of research has been focusing on the role of MSCs in human cancers, due to the potential oncological risk of using MSC-based strategies linked to their antiapoptotic, proangiogenic, and immunosuppressive properties. In the dermatological setting, ADSCs have shown not only to promote melanoma growth and invasiveness, but also to induce drug resistance. In contrast, genetically modified ADSCs have been demonstrated to efficiently target therapies at tumor sites, due to their migratory properties and their peculiar tropism for cancer microenvironment. The present review briefly summarizes the findings published so far on the use of ADSCs in the dermato-oncological setting, with the majority of data being available for melanoma.<\/jats:p>","DOI":"10.1089\/scd.2022.0189","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T09:37:00Z","timestamp":1662457020000},"page":"593-603","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The Dark Side of Adipose-Derived Mesenchymal Stromal Cells in Cutaneous Oncology: Roles, Expectations, and Potential Pitfalls"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-7769","authenticated-orcid":false,"given":"Alessia","family":"Paganelli","sequence":"first","affiliation":[{"name":"Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Rossi","sequence":"additional","affiliation":[{"name":"Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, Division of Dermatology, University of Modena and Reggio Emilia, Modena and Reggio Emilia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Magnoni","sequence":"additional","affiliation":[{"name":"Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, Division of Dermatology, University of Modena and Reggio Emilia, Modena and Reggio Emilia, Italy."},{"name":"Regenerative and Oncological Dermatologic Surgery Unit, Modena University Hospital, University of Modena and Reggio Emilia, Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-02-0105"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10413"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.1988.Supplement_10.5"},{"key":"e_1_3_3_5_2","first-page":"557","article-title":"Precursor cells for osteogenic and hemopoietic tissues","volume":"10","author":"Fridenshte\u012dn AI","year":"1968","unstructured":"Fridenshte\u012dn AI, , Petrakova KV, , Kuralesova AI, and Frolova GI. (1968). Precursor cells for osteogenic and hemopoietic tissues. Analysis of heterotopic transplants of bone marrow. Tsitologiia, 10:557\u2013567.","journal-title":"Analysis of heterotopic transplants of bone marrow. Tsitologiia"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2021.635055"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2019.0025"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2004-0058"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-0774.2010.00083.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1376-9"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(03)00107-1"},{"key":"e_1_3_3_13_2","first-page":"315","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells","volume":"8","author":"Dominici M","year":"2006","unstructured":"Dominici M, , Le Blanc K, , Mueller I, , Slaper-Cortenbach I, , Marini FC, , Krause DS, , Deans RJ, , Keating A, , Prockop DJ, and Horwitz EM. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy Position Statement. Cytotherapy, 8:315\u2013317.","journal-title":"The International Society for Cellular Therapy Position Statement. Cytotherapy"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3016"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2019.08.002"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0031"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpsc.29"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215471"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2017.04.032"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0520-7"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071101"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-020-00246-5"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-129"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/scrt454"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-017-9772-y"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.12.030"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-210409"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-021-00392-8"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001321"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06188"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246173"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01215.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-021-05186-4"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-4-48"},{"key":"e_1_3_3_35_2","first-page":"cm1","article-title":"Interleukin-1 (IL-1) pathway","volume":"3","author":"Weber A","year":"2010","unstructured":"Weber A, , Wasiliew P, and Kracht M. (2010). Interleukin-1 (IL-1) pathway. Sci Signal, 3:cm1.","journal-title":"Sci Signal"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.201"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.08.010"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2010.01.016"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181f74ca5"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e3182150d56"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr016"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1016-8478(23)17591-1"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.01.011"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.03.040"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.442"},{"key":"e_1_3_3_46_2","first-page":"3705","article-title":"MSC(TRAIL)- mediated HepG2 cell death in direct and indirect co-cultures","volume":"31","author":"Sun X-Y","year":"2011","unstructured":"Sun X-Y, , Nong J, , Qin K, , Lu H, , Moniri MR, , Dai L-J, and Warnock GL. (2011). MSC(TRAIL)- mediated HepG2 cell death in direct and indirect co-cultures. Anticancer Res, 31:3705\u20133712.","journal-title":"Anticancer Res"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2015.01.002"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2018.1489246"},{"key":"e_1_3_3_49_2","first-page":"USA","article-title":"Clinical guidelines for the staging diagnosis and management of cutaneous malignant melanoma","author":"Pathak S","year":"2022","unstructured":"Pathak S, and Zito PM. (2022). Clinical guidelines for the staging diagnosis and management of cutaneous malignant melanoma. StatPearls Publishing, Treasure Island, FL, USA.","journal-title":"StatPearls Publishing, Treasure Island, FL,"},{"key":"e_1_3_3_50_2","first-page":"141","article-title":"European consensus-based interdisciplinary guideline for melanoma","volume":"126","author":"Garbe C","year":"2020","unstructured":"Garbe C, , Amaral T, , Peris K, , Hauschild A, , Arenberger P, , Bastholt L, , Bataille V, , Del Marmol V, , Dr\u00e9no B, et al. (2020). European consensus-based interdisciplinary guideline for melanoma. part 1: diagnostics\u2014update 2019. Eur J Cancer, 126:141\u2013158.","journal-title":"part 1: diagnostics\u2014update 2019. Eur J Cancer"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000350227.61132.A7"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5283"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.07.013"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1865"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100455"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.10.003"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0046-y"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107836"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz398"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1490019"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.43"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3264217"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-019-0666-x"},{"key":"e_1_3_3_64_2","first-page":"63","article-title":"Cloning and expressing of interleukine 2 in amniotic membrane-derived mesenchymal stem cells as a potent feeder layer","volume":"10","author":"Anvari S","year":"2021","unstructured":"Anvari S, , Foroughi F, , Azad M, , Maali A, , Alizadeh S, and Ahmadi MH. (2021). Cloning and expressing of interleukine 2 in amniotic membrane-derived mesenchymal stem cells as a potent feeder layer. Mol Biol Res Commun, 10:63\u201371.","journal-title":"Mol Biol Res Commun"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2014.988719"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1159\/000501071"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.33296"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.913080"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28589"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1364-0"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.21725"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1103a68"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11162541"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9050532"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2022.101746"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010049"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-0951-9"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2014.10.045"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-4-24"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.21.6.066016"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00632-5"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073727"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S158513"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190703153730"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.606"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-013-0116-2"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.05.009"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X14666190318111614"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X12666161114122059"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2395"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.24110"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01997-8"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080784"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051157"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2473-5"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.182682"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27472"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368915X689622"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-04588-y"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11121926"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-020-10110-w"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/394917"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041306"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4806.20.07205-5"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2575"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2016.10.008"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8973613"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071450"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-016-0143-0"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01513-7"},{"key":"e_1_3_3_111_2","first-page":"184","article-title":"Gene engineered mesenchymal stem cells: greater transgene expression and efficacy with minicircle vs","volume":"12","author":"Florian M","year":"2021","unstructured":"Florian M, , Wang J-P, , Deng Y, , Souza-Moreira L, , Stewart DJ, and Mei SHJ. (2021). Gene engineered mesenchymal stem cells: greater transgene expression and efficacy with minicircle vs. plasmid dna vectors in a mouse model of acute lung injury. Stem Cell Res Ther, 12:184.","journal-title":"plasmid dna vectors in a mouse model of acute lung injury. Stem Cell Res Ther"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12090896"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2020.112915"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218103"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.2912"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v12.i9.966"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.573877"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2018.01.009"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70263-3"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3962"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.12.027"},{"key":"e_1_3_3_123_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0416"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1027-0"},{"key":"e_1_3_3_125_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1447-y"},{"key":"e_1_3_3_126_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01208-w"}],"container-title":["Stem Cells and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/scd.2022.0189","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/scd.2022.0189","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/scd.2022.0189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:00:53Z","timestamp":1777687253000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/scd.2022.0189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":125,"journal-issue":{"issue":"19-20","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1089\/scd.2022.0189"],"URL":"https:\/\/doi.org\/10.1089\/scd.2022.0189","relation":{},"ISSN":["1547-3287","1557-8534"],"issn-type":[{"value":"1547-3287","type":"print"},{"value":"1557-8534","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]}}}