{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T06:59:03Z","timestamp":1782543543051,"version":"3.54.5"},"reference-count":40,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    Seipin deficiency is an important cause of type 2 Berardinelli-Seip congenital dyslipidemia (BSCL2). BSCL2 is a severe lipodystrophy syndrome with lack of adipose tissue, hepatic steatosis, insulin resistance, and normal or higher bone mineral density. Bone marrow mesenchymal stem cells (BMSCs) are believed to maintain bone and fat homeostasis by differentiating into osteoblasts and adipocytes. We aimed to explore the role of seipin in the osteogenic\/adipogenic differentiation balance of BMSCs. Seipin loxP\/loxP mice are used to explore metabolic disorders caused by\n                    <jats:italic toggle=\"yes\">seipin<\/jats:italic>\n                    gene mutations. Compared with wild-type mice, subcutaneous fat deficiency and ectopic fat accumulation were higher in seipin knockout mice. Microcomputed tomography of the tibia revealed the increased bone content in seipin knockout mice. We generated seipin-deficient BMSCs in vitro and revealed that lipogenic genes are downregulated and osteogenic genes are upregulated in seipin-deficient BMSCs. In addition, peroxisome proliferator-activated receptor gamma (PPAR\u03b3) signaling is reduced in seipin-deficient BMSCs, while using the PPAR\u03b3 activator increased the lipogenic differentiation and decreased osteogenic differentiation of seipin-deficient BMSCs. Our findings indicated that bone and lipid metabolism can be regulated by seipin through modulating the differentiation of mesenchymal stem cells. Thus, a new insight of seipin mutations in lipid metabolism disorders was revealed, providing a prospective strategy for MSC transplantation-based treatment of BSCL2.\n                  <\/jats:p>","DOI":"10.1089\/scd.2023.0107","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T12:14:54Z","timestamp":1708604094000},"page":"177-188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Seipin on Mouse Mesenchymal Stem Cell Osteo-Adipogenic Balance"],"prefix":"10.1177","volume":"33","author":[{"given":"Zeying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology, Central People's Hospital of Zhanjiang and Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Central People's Hospital of Zhanjiang and Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Central People's Hospital of Zhanjiang and Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Chen","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University) Shihezi, China."},{"name":"Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenping","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Central People's Hospital of Zhanjiang and Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pathology, Central People's Hospital of Zhanjiang and Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Central People's Hospital of Zhanjiang and Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihui","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Central People's Hospital of Zhanjiang and Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Central People's Hospital of Zhanjiang and Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Gu","sequence":"additional","affiliation":[{"name":"Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3091-0323","authenticated-orcid":false,"given":"Lijuan","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Central People's Hospital of Zhanjiang and Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06465-11"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2019.03.005"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2020.158610"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.037"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.11.009"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.09.010"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr205"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz300"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.04.012"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.11.004"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.168"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124283"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-05038-x"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng585"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030835"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2016.10.002"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201701427R"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2019.04.008"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.782194"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.04.001"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13102"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-2926-9"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-021-01615-5"},{"key":"e_1_3_6_25_2","first-page":"1615","article-title":"Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARgamma","volume":"8","author":"Li G","year":"2015","unstructured":"Li G, , Zhou L, , Zhu Y, , Wang C, , Sha S, , Xian X, , Ji Y, , Liu G, and Chen L. (2015). Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARgamma. Dis Model Mech, 8:1615\u20131624.","journal-title":"Dis Model Mech"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0236"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0184"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002201"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.03.023"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-04036-7"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2013.06.001"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2017.tb00753.x"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519870723"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S206695"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1211-2"},{"key":"e_1_3_6_36_2","first-page":"19","article-title":"Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment","author":"Hu L","year":"2018","unstructured":"Hu L, , Yin C, , Zhao F, , Ali A, , Ma J, and Qian A. (2018). Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment. Int J Mol Sci. 19.","journal-title":"Int J Mol Sci"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.10.033"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23062927"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02463-x"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0239"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01731-6"}],"container-title":["Stem Cells and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/scd.2023.0107","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/scd.2023.0107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/scd.2023.0107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:01:17Z","timestamp":1777687277000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/scd.2023.0107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":40,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1089\/scd.2023.0107"],"URL":"https:\/\/doi.org\/10.1089\/scd.2023.0107","relation":{},"ISSN":["1547-3287","1557-8534"],"issn-type":[{"value":"1547-3287","type":"print"},{"value":"1557-8534","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]}}}