{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:48:04Z","timestamp":1790837284522,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"19-20","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>\n                    Although enhanced fibroblast growth factor (FGF) signaling has been demonstrated to be crucial in many cases of syndromic cleft palate caused by tongue malposition in humans, animal models that recapitulate this phenotype are limited, and the precise mechanisms remain elusive. Mutations in\n                    <jats:italic toggle=\"yes\">FGF9<\/jats:italic>\n                    with the effect of either loss- or gain-of-function effects have been identified to be associated with cleft palate in humans. Here, we generated a mouse model with a transgenic\n                    <jats:italic toggle=\"yes\">Fgf9<\/jats:italic>\n                    allele specifically activated in cranial neural crest cells, aiming to elucidate the gain-of-function effects of\n                    <jats:italic toggle=\"yes\">Fgf9<\/jats:italic>\n                    in palatogenesis. We observed cleft palate with 100% penetrance in mutant mice. Further analysis demonstrated that no inherent defects in the morphogenic competence of palatal shelves could be found, but a passively lifted tongue prevented the elevation of palatal shelves, leading to the cleft palate. This tongue malposition was induced by posterior spatial confinement that was exerted by temporomandibular joint (TMJ) dysplasia characterized by a reduction in Sox9+ progenitors within the condyle and a structural decrease in the posterior dimension of the lower jaw. Our findings highlight the critical role of excessive FGF signaling in disrupting spatial coordination during palate development and suggest a potential association between palatal shelf elevation and early TMJ development.\n                  <\/jats:p>","DOI":"10.1089\/scd.2024.0077","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T06:00:32Z","timestamp":1723183232000},"page":"562-573","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Cleft Palate Induced by Augmented Fibroblast Growth Factor-9 Signaling in Cranial Neural Crest Cells in Mice"],"prefix":"10.1177","volume":"33","author":[{"given":"Chensheng","family":"Lin","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory of Developmental and Neural Biology &amp; Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Developmental and Neural Biology &amp; Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningsheng","family":"Ruan","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Developmental and Neural Biology &amp; Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases &amp; Fujian Provincial Engineering Research Center of Oral Biomaterial &amp; Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiPing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanding","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Developmental and Neural Biology &amp; Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0286-2144","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases &amp; Fujian Provincial Engineering Research Center of Oral Biomaterial &amp; Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, P.R. China."},{"name":"Chinese Institute for Brain Research, Beijing, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607956104"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.463620"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20384"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.09.010"},{"key":"e_1_3_6_6_2","first-page":"768","article-title":"From shape to cells: Mouse models reveal mechanisms altering palate development in Apert syndrome","volume":"6","author":"Mart\u00ednez-Abad\u00edas N","year":"2013","unstructured":"Mart\u00ednez-Abad\u00edas N, , Holmes G, , Pankratz T, et al. From shape to cells: Mouse models reveal mechanisms altering palate development in Apert syndrome. 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