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The use of PSAs in compression therapy has proven promising in proactive pressure delivery with a wide range of dosages for treatment of chronic venous insufficiency and lymphedema. However, effective design and control of PSAs for dynamic pressure delivery have not been fully elaborated. The purpose of this study is to explore interactive working mechanisms between a PSA and lower limbs through establishing fluid\u2013structure coupling models, an intermittent pneumatic compression (IPC) testing system, and conducting experimental validation. The developed IPC testing system consisted of a PSA unit (multichambered bladders laminated with an external textile shell), a pneumatic controller, and various real-time pressure monitoring sensors and accessory elements. The established coupling model characterized the dynamic response process with varying design parameters of the PSA unit, and demonstrated that the design of initial thickness, stiffness, and air mass flow of the PSA, as well as stiffness of limb tissues of the users, influenced PSA-lower limb interactions and resultant pressure dosages. The simulated results presented a favorable agreement with the experimental data collected by the IPC testing system. This study enhanced understanding of PSA-lower limb interactive working mechanisms and provided an evidence-based technical guidance for functional design of PSA. These results contribute to improving the efficacy of dynamic compression therapy for promotion of venous hemodynamics and user compliance in practice.<\/jats:p>","DOI":"10.1089\/soro.2019.0035","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T15:40:55Z","timestamp":1582645255000},"page":"627-638","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Fluid\u2013Structure Coupling Model and Experimental Validation of Interaction Between Pneumatic Soft Actuator and Lower Limb"],"prefix":"10.1177","volume":"7","author":[{"given":"Dong","family":"Guan","sequence":"first","affiliation":[{"name":"Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Kowloon, Hong Kong."},{"name":"College of Mechanical Engineering, Yangzhou University, Yangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Kowloon, Hong Kong."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Fei","sequence":"additional","affiliation":[{"name":"Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Kowloon, Hong Kong."},{"name":"Department of Aeronautics and Astronautics, Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Kowloon, Hong Kong."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiao","family":"Jing","sequence":"additional","affiliation":[{"name":"Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Kowloon, Hong Kong."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1109\/TMECH.2016.2638468"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14543"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615140114"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704446"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1088\/1748-3182\/9\/1\/016007"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/soro.2013.0009"},{"key":"e_1_3_4_8_2","first-page":"180408692","article-title":"Switchable adhesion actuator for amphibious climbing soft robot","author":"Tang Y","year":"2018","unstructured":"Tang Y, , Zhang Q, , Lin G, et al. 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