{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:16:49Z","timestamp":1779218209005,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Antibiotic prophylaxis guidelines suggest single-dose regimens are adequate, but comparisons of multiple agents are lacking. We compared post-operative infection rates retrospectively among six common prophylactic agents given as a single dose to colorectal surgery patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A commercial database supplied demographics, All-Patient Refined Diagnosis-Related Groups (APR DRGs), International Classification of Disease (ICD)-9 codes, and drug utilization information for patients discharged from 303 hospitals from January 2007\u2013December 2008 whose charts had been sampled for reporting Surgical Care Improvement Project (SCIP) measures. The patients (n=4,634) had the same APR DRG, no baseline infection, and prophylaxis discontinued within 24\u2009h of surgery. Development of infection was determined by ICD-9 code. \u201cSingle dose\u201d was defined as \u22643\u2009g of ampicillin\u2013sulbactam (AMP); \u22642\u2009g of cefotetan (CFT), cefoxitin (FOX), or ertapenem (ERT); or metronidazole and \u22642\u2009g of cefazolin (CFZ) or \u2264750\u2009mg of levofloxacin (LVX) given on the day of the procedure. Multivariable logistic regression evaluated factors associated with infection, including agent choice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Frequency of use and rate of infection (3.7% overall) were FOX 1,752 (4.9%), ERT 1,166 (2.7%), CFZ 549 (2.7%), AMP 447 (3.6%), LVX 402 (3.2%), and CFT 318 (3.5%). The unadjusted infection rate differed by agent (p=0.037). Multiple regression analysis found infection to be associated significantly with increasing APR DRG severity, longer procedures, younger age, and male gender (p&lt;0.01 for each except p=0.02 for age), as well as agent choice. Among agents (vs. FOX as reference), ERT was associated with a lower infection rate (odds ratio 0.53; 95% confidence interval 0.34\u20130.82; p&lt;0.01); the odds ratio for all other agents contained the value 1.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Agent selection among prophylactic antibiotics is one of many factors associated with infection development in colorectal surgery patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/sur.2010.108","type":"journal-article","created":{"date-parts":[[2011,12,5]],"date-time":"2011-12-05T12:12:41Z","timestamp":1323087161000},"page":"451-457","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Selection of Prophylactic Antimicrobial Agent May Affect Incidence of Infection in Small Bowel and Colorectal Surgery"],"prefix":"10.1177","volume":"12","author":[{"given":"Kathryn J.","family":"Eagye","sequence":"first","affiliation":[{"name":"Hartford Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Hartford Hospital"},{"name":"Hartford Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,12,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/501572"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2006.7.s1-19"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.11.030"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200108000-00007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(98)00132-X"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000124292.21605.99"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2009.10.001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2010.073"},{"issue":"1","key":"e_1_3_3_10_2","first-page":"CD001181","article-title":"Antimicrobial prophylaxis for colorectal surgery","author":"Nelson RL","year":"2009","unstructured":"Nelson RL, , Glenny AM, , Song F. Antimicrobial prophylaxis for colorectal surgery. Cochrane Database Syst Rev, 2009; 1:CD001181.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554782"},{"key":"e_1_3_3_12_2","first-page":"245","article-title":"Single versus multiple dose doxycycline prophylaxis in elective colorectal surgery","volume":"150","author":"Goransson G","year":"1984","unstructured":"Goransson G, , Nilsson-Ehle I, , Olsson SA et al. Single versus multiple dose doxycycline prophylaxis in elective colorectal surgery. Acta Chir Scand, 1984; 150:245\u2013249.","journal-title":"Acta Chir Scand"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.142.7.657"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199508000-00006"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.841"},{"key":"e_1_3_3_16_2","unstructured":"Hart AC Hopkins CA Ford B. 2006 ICD-9-CM Professional for Hospitals Volumes 1\u20133 International Classification of Diseases 9th Revision Clinical Modification. 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A multicenter randomized trial of prophylaxis with intravenous cefepime + metronidazole or ceftriaxone + metronidazole in colorectal surgery. The 230 Study Group. 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