{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:10:26Z","timestamp":1787008226661,"version":"build-2736575974"},"reference-count":45,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T00:00:00Z","timestamp":1408060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Infections caused by\n                      <jats:italic toggle=\"yes\">Nocardia farcinica<\/jats:italic>\n                      are potentially lethal because of the organism's tendency to disseminate and resist antibiotics. Central nervous system involvement has been documented in 30% of infections caused\n                      <jats:italic toggle=\"yes\">N. farcinica<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Case report and review of the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A case of primary brain abscess caused by\n                      <jats:italic toggle=\"yes\">N. farcinica,<\/jats:italic>\n                      identified by 16SrRNA sequencing, is presented, and 39 cases reported previously in the literature are reviewed. Our patient underwent a neuronavigation-guided right frontal craniotomy and was treated with trimethoprim\/sulfamethoxazole and amoxicillin-clavulanic acid for 12 mo. He showed marginal improvement in his prior left hemiparesis at the last review 14 months later.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Cases of\n                      <jats:italic toggle=\"yes\">N. farcinica<\/jats:italic>\n                      infections are being reported increasingly because of recent changes in taxonomy and diagnostic methodology. This change in epidemiology has implications for therapy because of the organism's pathogenicity and natural resistance to multiple antimicrobial agents, including third-generation cephalosporins. Any delay in starting appropriate antibiotic therapy can have adverse consequences.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/sur.2012.205","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T16:46:31Z","timestamp":1408121191000},"page":"640-646","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["<i>Nocardia farcinica<\/i>\n                    Brain Abscess: Epidemiology, Pathophysiology, and Literature Review"],"prefix":"10.1177","volume":"15","author":[{"given":"V. Anil","family":"Kumar","sequence":"first","affiliation":[{"name":"Amrita Institute of Medical Sciences","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepthi","family":"Augustine","sequence":"additional","affiliation":[{"name":"Cochin University of Science and Technology","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip","family":"Panikar","sequence":"additional","affiliation":[{"name":"Amrita Institute of Medical Sciences","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aswathy","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"Amrita Institute of Medical Sciences","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha R.","family":"Dinesh","sequence":"additional","affiliation":[{"name":"Amrita Institute of Medical Sciences","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamsul","family":"Karim","sequence":"additional","affiliation":[{"name":"Amrita Institute of Medical Sciences","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosamma","family":"Philip","sequence":"additional","affiliation":[{"name":"Cochin University of Science and Technology","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,8,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.03.017"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.5.1165"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1473(04)70453-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199410000-00007"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.7.2.213"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01989975"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00362177585190301"},{"key":"e_1_3_2_9_2","first-page":"2273","volume-title":"Principles and Practice of Infectious Diseases","author":"Lerner PI","year":"1995","unstructured":"Lerner PI. Nocardia species. In: Mandel GL, , Douglas R, , Bennet JE (eds). Principles and Practice of Infectious Diseases. New York. Churchill Livingstone, 1995:2273\u20132280."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.2.382"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.2.851-856.2003"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01780852"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2011.50.4.396"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-1978-6"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.28.12.2726-2732.1990"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.02.019"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01974641"},{"key":"e_1_3_2_18_2","first-page":"613","article-title":"Therapie eines Hirnabszesses, verursacht durch Nocardia farcinica","volume":"83","author":"Dietlein E","year":"1988","unstructured":"Dietlein E, , Firsching R, , Peters G. Therapie eines Hirnabszesses, verursacht durch Nocardia farcinica. Med Klin, 1988; 83:613\u2013614.","journal-title":"Med Klin"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-008-1578-x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.2.259-282.2006"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688690701365770"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/6.3.209"},{"key":"e_1_3_2_23_2","first-page":"542","article-title":"A case of disseminated Nocardia farcinica diagnosed through DNA sequencing in a kidney transplantation patient","volume":"70","author":"Park BS","year":"2002","unstructured":"Park BS, , Park YJ, , Kim YJ, et al. A case of disseminated Nocardia farcinica diagnosed through DNA sequencing in a kidney transplantation patient. Clin Nephrol, 2002; 70:542\u2013545.","journal-title":"Clin Nephrol"},{"key":"e_1_3_2_24_2","first-page":"356","article-title":"Infection diss\u00e9min\u00e9e due \u00e0 un germe inhabituel, Nocardia farcinica","volume":"10","author":"Debieuvre D","year":"1993","unstructured":"Debieuvre D, , Dalphin JC, , Jacoulet P, et al. Infection diss\u00e9min\u00e9e due \u00e0 un germe inhabituel, Nocardia farcinica. Rev Mal Respir, 1993; 10:356\u2013358.","journal-title":"Rev Mal Respir"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365549509018968"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.6.891"},{"key":"e_1_3_2_27_2","first-page":"75","article-title":"Systemic Nocardia infection","volume":"47","author":"Bergstr\u00f6m R","year":"1996","unstructured":"Bergstr\u00f6m R, , Edebo L, , Fors B, , Tegner KB. Systemic Nocardia infection. Scand J Respir Dis, 1996; 47:75\u201384.","journal-title":"Scand J Respir Dis"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197409000-00005"},{"key":"e_1_3_2_29_2","first-page":"1062","article-title":"Aspects cliniques et bact\u00e9riologiques des nocardioses: 9 observations","volume":"24","author":"Bani-Sadr F","year":"1995","unstructured":"Bani-Sadr F, , Hamidou M, , Raffi F, et al. Aspects cliniques et bact\u00e9riologiques des nocardioses: 9 observations. Presse M\u00e9d, 1995; 24:1062\u20131066.","journal-title":"Presse M\u00e9d"},{"key":"e_1_3_2_30_2","first-page":"379","volume-title":"Manual of Clinical Microbiology","author":"Beaman BL","year":"1995","unstructured":"Beaman BL, et al. Nocardia, Rhodococcus, Streptomyces, Oerskovia and other actinomycetes of medical importance. In: Murray PP, , Baron EJ, , Pfaller MA, et al. (eds): Manual of Clinical Microbiology. Washington, DC. American Society for Microbiology. 1995:379\u2013399."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027469"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1086\/517039"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199807000-00004"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(01)00201-3"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46084-0"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.08.001"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2006.00141.x"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46774-0"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-194"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2009.03.029"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2008.02.025"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.05.011"},{"key":"e_1_3_2_43_2","first-page":"13","article-title":"Nocardia farcinica as the causative agent of a brain abscess in a patient with interstitial lung disease","volume":"59","author":"Scharfen J","year":"2010","unstructured":"Scharfen JJr, , Mor\u00e1vkov\u00e1 M, , Buncek M, et al. Nocardia farcinica as the causative agent of a brain abscess in a patient with interstitial lung disease. Epidemiol Mikrobiol Imunol, 2010; 59:13\u201320.","journal-title":"Epidemiol Mikrobiol Imunol"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.025577-0"},{"key":"e_1_3_2_45_2","first-page":"1167","article-title":"Two cases of Nocardia farcinica brain abscess","volume":"39","author":"Izawa D","year":"2011","unstructured":"Izawa D, , Sakano K, , Okumura H, et al. Two cases of Nocardia farcinica brain abscess. No Shinkei Geka, 2011; 39:1167\u20131172.","journal-title":"No Shinkei Geka"},{"key":"e_1_3_2_46_2","first-page":"930","article-title":"Idiopathic CD4+ T lymphocytopenia with epidermodysplasia verruciformis-like skin eruption, Nocardia farcinica brain abscesses and pulmonary tuberculosis: A case report with fatal outcome","volume":"38","author":"G\u00f6ktay F","year":"2011","unstructured":"G\u00f6ktay F, , Mansur AT, , Er\u015fahin M, et al. Idiopathic CD4+ T lymphocytopenia with epidermodysplasia verruciformis-like skin eruption, Nocardia farcinica brain abscesses and pulmonary tuberculosis: A case report with fatal outcome. J Dermatol, 2011; 38:930\u2013933.","journal-title":"J Dermatol"}],"container-title":["Surgical Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/sur.2012.205","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/sur.2012.205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/sur.2012.205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:18:16Z","timestamp":1777688296000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/sur.2012.205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,15]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10,1]]}},"alternative-id":["10.1089\/sur.2012.205"],"URL":"https:\/\/doi.org\/10.1089\/sur.2012.205","relation":{},"ISSN":["1096-2964","1557-8674"],"issn-type":[{"value":"1096-2964","type":"print"},{"value":"1557-8674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,15]]}}}