{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:38:28Z","timestamp":1777934308574,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                      infections are associated commonly with immunocompromised states, such as transplantation and hematologic malignant disease. Although\n                      <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                      infections among patients having surgery occur primarily in transplant recipients, they are found in non-recipients of transplants, and have a mortality rate similar to that seen among transplant recipients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective analysis of a prospective data base collected from 1996 to 2010, in which we identified patients with\n                      <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                      infections. We compared demographic data, co-morbidities, and outcomes in non-transplant patients with those in abdominal transplant recipients. Continuous data were evaluated with the Student\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test, and categorical data were evaluated through \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twenty-three patients (11 transplant patients and 12 non-transplant patients) were identified as having had\n                      <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                      infections. The two groups were similar with regard to their demographics and co-morbidities, with the exceptions of their scores on the Acute Physiology and Chronic Health Evaluation II (APACHE II), of 23.6\u00b18.1 points for transplant patients vs. 16.8\u00b16.1 points for non-transplant patients (p=0.03); Simplified Acute Physiology Score (SAPS) of 16.6\u00b18.3 points vs. 9.2\u00b14.1 points, respectively (p=0.02); steroid use 91.0% vs. 25.0%, respectively (p=0.003); and percentage of infections acquired in the intensive care unit (ICU) 27.3% vs. 83.3%, respectively (p=0.01). The most common site of infection in both patient groups was the lung. The two groups showed no significant difference in the number of days from admission to treatment, hospital length of stay following treatment, or mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Although\n                      <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                      infections among surgical patients have been associated historically with solid-organ transplantation, our data suggest that other patients may also be susceptible to such infections, especially those in an ICU who are deemed to be critically ill. This supports the idea that critically ill surgical patients exist in an immunocompromised state. Surgical intensivists should be familiar with the diagnosis and treatment of\n                      <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                      infections even in the absence of an active transplant program.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/sur.2012.239","type":"journal-article","created":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T20:02:00Z","timestamp":1399320120000},"page":"207-212","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["<i>Aspergillus<\/i>\n                    Infections in Transplant and Non-Transplant Surgical Patients"],"prefix":"10.1177","volume":"15","author":[{"given":"Stephen","family":"Davies","sequence":"first","affiliation":[{"name":"University of Virginia Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Guidry","sequence":"additional","affiliation":[{"name":"University of Virginia Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amani","family":"Politano","sequence":"additional","affiliation":[{"name":"University of Virginia Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Rosenberger","sequence":"additional","affiliation":[{"name":"University of Virginia Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"McLeod","sequence":"additional","affiliation":[{"name":"University of Virginia Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjasa","family":"Hranjec","sequence":"additional","affiliation":[{"name":"University of Virginia Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sawyer","sequence":"additional","affiliation":[{"name":"University of Virginia Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,5,5]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Prevention CDC. Aspergillosis. Last updated 2012; Available from: www.cdc.gov\/fungal\/aspergillosis\/. Accessed April18 2012."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767110-00004"},{"key":"e_1_3_2_4_2","first-page":"1655","volume-title":"Harrison's Principles of Internal Medicine","author":"Denning DW","year":"2012","unstructured":"Denning DW. Aspergillosis. In: Longo DL, , Fauci AS, , Kasper DL, et al. (eds). Harrison's Principles of Internal Medicine, 18th ed. New York. McGraw-Hill; 2012: 1655\u20131660.","edition":"18"},{"key":"e_1_3_2_5_2","first-page":"347","volume-title":"Current Diagnosis and Treatment: Surgery","author":"Theodore PR","year":"2010","unstructured":"Theodore PR, , Jablons DM. Thoracic wall, pleura, mediastinum, and lung. In: Doherty GM, ed. Current Diagnosis and Treatment: Surgery, 13th ed. New York: Lange Medical Books\/McGraw-Hill, 2010, pp. 347\u2013348.","edition":"13"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00054810"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200906-050AL"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0791-z"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0792-y"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc4823"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3488"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020191"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/323335"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000196477"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02044.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-010-0132-1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1778-z"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2011.614307"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2004.037"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.1995.tb00356.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/106286060101600503"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199204000-00014"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2002.t01-2-02002.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780701200372"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12060"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)00477-1"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.03.013"}],"container-title":["Surgical Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/sur.2012.239","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/sur.2012.239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/sur.2012.239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:18:22Z","timestamp":1777688302000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/sur.2012.239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,5]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6,1]]}},"alternative-id":["10.1089\/sur.2012.239"],"URL":"https:\/\/doi.org\/10.1089\/sur.2012.239","relation":{},"ISSN":["1096-2964","1557-8674"],"issn-type":[{"value":"1096-2964","type":"print"},{"value":"1557-8674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,5]]}}}