{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:38:36Z","timestamp":1777934316145,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n In August 2010, the U.S. Food and Drug Administration issued draft guidelines for developing antibiotics for treating acute bacterial skin and skin structure infections (ABSSSI), with the outcome measure of such treatment relying primarily on the cessation of spread or on the decrease in size of skin lesions at 48\u201372\u2009h after the initiation of such treatment. In 2012, the Foundation for the National Institutes of Health proposed an interim outcome measure defined as a reduction in lesion size by \u226520% at a 48\u201372\u2009h examination. These recent changes make it necessary to identify reliable methods for measuring the lesions in acute infections of the skin.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In the first study of the Efficacy and Safety of 6-day Oral Tedizolid in Acute Bacterial Skin and Skin Structure Infections vs. 10-day Oral Linezolid Therapy (ESTABLISH\u20131), the sizes of ABSSSI lesions were evaluated with the two methodologies of: (1) Digital planimetry (DP) of photographed lesions, and (2) a ruler technique (RT) with measurement of the longest head-to-toe length and greatest perpendicular width of lesions, to compare the respective response rates of lesions to the two antimicrobial regimens in the study.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The RT method and DP showed similar percentages of subjects in which treatment stopped the spread of ABSSSI lesions (93.2% vs. 94.2%, respectively) but showed less agreement for a reduction in lesion size, of \u226520% (87.7% vs. 62.0%, respectively) across all categories of lesions (cellulitis\/erysipelas, major cutaneous abscess, and acute wound infection) at 48\u201372\u2009h after the initiation of treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The results of the ESTABLISH\u20131 study show that both the RT method and DP are consistent and reliable techniques for measuring the sizes of ABSSSI lesions. Ultimately, changes in lesion size, rather than the absolute value of lesion size, will be used to assess the outcomes of treatment for ABSSSI in clinical research.<\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/sur.2013.070","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T17:20:31Z","timestamp":1390411231000},"page":"105-110","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of Digital Planimetry and Ruler Technique To Measure ABSSSI Lesion Sizes in the ESTABLISH\u20131 Study"],"prefix":"10.1177","volume":"15","author":[{"given":"Paul","family":"Bien","sequence":"first","affiliation":[{"name":"Cubist Pharmaceuticals"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carisa","family":"De Anda","sequence":"additional","affiliation":[{"name":"Cubist Pharmaceuticals"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Prokocimer","sequence":"additional","affiliation":[{"name":"Cubist Pharmaceuticals"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,22]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"US Food and Drug Administration. Guidance for industry: Uncomplicated and complicated skin and skin structure infections\u2014Developing antimicrobial drugs for treatment (draft guidance). July 1998. http:\/\/www.fda.gov\/ohrms\/dockets\/ac\/03\/briefing\/3997B1_02_GFI-Diabetic%20Foot.pdf"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir162"},{"key":"e_1_3_3_4_2","unstructured":"US Food and Drug Administration. Guidance for industry: Acute bacterial skin and skin structure infections: Developing drugs for treatment (draft guidance). August 2010. http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatory\/Information\/Guidances\/UCM071185.pdf"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis566"},{"key":"e_1_3_3_6_2","first-page":"28","article-title":"Improving accuracy of wound measurement in clinical practice","volume":"49","author":"Flanagan M","year":"2003","unstructured":"Flanagan M. Improving accuracy of wound measurement in clinical practice. Ostomy Wound Manage, 2003; 49:28\u201340.","journal-title":"Ostomy Wound Manage"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129334-200604000-00009"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.1998.7.13.5646"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000284967.69863.2f"},{"key":"e_1_3_3_10_2","first-page":"60","article-title":"The importance of continuous wound measuring","volume":"2","author":"Gethin H","year":"2006","unstructured":"Gethin H. The importance of continuous wound measuring. Wounds UK, 2006; 2:60\u201368.","journal-title":"Wounds UK"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/193229681000400405"},{"key":"e_1_3_3_12_2","first-page":"267","article-title":"Wounds measured from digital photographs using photo-digital planimetry software: Validation and rater reliability","volume":"23","author":"Wendelken ME","year":"2011","unstructured":"Wendelken ME, , Berg WE, , Lichtenstein P, et al. Wounds measured from digital photographs using photo-digital planimetry software: Validation and rater reliability. Wounds, 2011; 23:267\u2013275.","journal-title":"Wounds"},{"key":"e_1_3_3_13_2","first-page":"37","article-title":"Methods for assessing change in ulcer status","volume":"8","author":"Harding KG","year":"1995","unstructured":"Harding KG. Methods for assessing change in ulcer status. Adv Wound Care, 1995; 8 Suppl:37\u201342.","journal-title":"Adv Wound Care"}],"container-title":["Surgical Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/sur.2013.070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/sur.2013.070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/sur.2013.070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:18:38Z","timestamp":1777688318000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/sur.2013.070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,22]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4,1]]}},"alternative-id":["10.1089\/sur.2013.070"],"URL":"https:\/\/doi.org\/10.1089\/sur.2013.070","relation":{},"ISSN":["1096-2964","1557-8674"],"issn-type":[{"value":"1096-2964","type":"print"},{"value":"1557-8674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,22]]}}}