{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:38:36Z","timestamp":1777934316879,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T00:00:00Z","timestamp":1399334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Macrolide-based treatment has been associated with survival benefit in patients hospitalized with community-acquired pneumonia (CAP). However, the influence of macrolide therapy in all patients hospitalized with pneumonia, including healthcare-associated pneumonia (HCAP), is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Analysis of a retrospective single-center cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Community-acquired pneumonia was present in 220 (22.5%) of all patients with pneumonia admitted through the emergency department of Barnes-Jewish Hospital, and HCAP was present in 757. Macrolide-based treatment was administered to 411 patients (42.1%). These patients were more likely to have CAP than were patients not receiving macrolide-based therapy (35.3% vs. 13.3%; p&lt;0.001) and had lower scores on the CURB-65 tool, a measure of the severity of illness (2.4\u00b11.5 vs. 3.1\u00b11.3; p&lt;0.001). Patients receiving macrolides also had a lower hospital mortality rate in univariable analysis (12.7% vs. 27.2%; p&lt;0.001). A propensity score analysis showed that macrolide-based treatment was associated with a lower in-hospital mortality rate (adjusted odds ratio [AOR] 0.67; 95% confidence interval [CI] 0.54\u20130.81; p=0.043). Separate propensity score analyses of patients with CAP (AOR 0.20; 95% CI 0.11\u20130.34; p=0.003) and HCAP (AOR 0.81; 95% CI 0.65\u20131.01; p=0.337) produced discordant findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Macrolide-based treatment was associated with better survival in patients hospitalized with pneumonia. The survival advantage appeared predominantly among patients with CAP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/sur.2013.076","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T15:52:08Z","timestamp":1399391528000},"page":"283-289","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Macrolides Are Associated with a Better Survival Rate in Patients Hospitalized with Community-Acquired But Not Healthcare-Associated Pneumonia"],"prefix":"10.1177","volume":"15","author":[{"given":"Colleen","family":"McEvoy","sequence":"first","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott T.","family":"Micek","sequence":"additional","affiliation":[{"name":"Barnes-Jewish Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Reichley","sequence":"additional","affiliation":[{"name":"Barnes-Jewish Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Kan","sequence":"additional","affiliation":[{"name":"Barnes-Jewish Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Hoban","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"St. Louis College of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew F.","family":"Shorr","sequence":"additional","affiliation":[{"name":"Washington Hospital Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marin H.","family":"Kollef","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,5,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2010.03.2130"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.216476"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/511159"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/367541"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1426"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00054108"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis414"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/526355"},{"key":"e_1_3_2_10_2","first-page":"CD004418","article-title":"Empiric antibiotic coverage of atypical pathogens for community-acquired pneumonia in hospitalized adults","volume":"9","author":"Eliakim-Raz N","year":"2012","unstructured":"Eliakim-Raz N, , Robenshtok E, , Shefet D, et al. 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