{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:38:36Z","timestamp":1777934316892,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Infections caused by multi-drug-resistant organisms are too common and represent a therapeutic challenge. Topical application of sevoflurane may be useful for the treatment of cutaneous infections, as this general anesthetic has antimicrobial properties in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report:<\/jats:title>\n                    <jats:p>\n                      A 43-year-old male patient received a liver transplant because of cirrhosis caused by hepatitis C. The surgical site was infected initially by multi-drug-resistant\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      that was susceptible to colistin, but parenteral administration of this antibiotic led to deterioration of renal function and was discontinued. The incision did not heal with daily lavage and debridement and was superinfected with\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      . The off-label use of liquid sevoflurane in the form of site irrigations was followed by healing and closure of the site. This healing could be attributable to the mixed effect of three possible actions of sevoflurane: Direct antimicrobial effect, local analgesic effect that improved the quality of the dressings, and a direct vasodilator effect that, in theory, increased the supply of nutrients to the incision bed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The use of liquid sevoflurane on sites infected by microorganisms resistant to conventional antibiotics appears to be an attractive therapeutic option that deserves future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/sur.2013.079","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T23:54:28Z","timestamp":1416441268000},"page":"843-846","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Topical Sevoflurane and Healing of a Post-Operative Surgical Site Superinfected by Multi-Drug-Resistant\n                    <i>Pseudomonas aeruginosa<\/i>\n                    and Susceptible\n                    <i>Staphylococcus aureus<\/i>\n                    in an Immunocompromised Patient"],"prefix":"10.1177","volume":"15","author":[{"given":"Juan Luis","family":"Rueda-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Complejo Hospitalario Universitario","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Ger\u00f3nimo-Pardo","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Mart\u00ednez-Monsalve","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Mart\u00ednez-Serrano","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,11,19]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.3.319"},{"key":"e_1_3_1_3_2","first-page":"5814","article-title":"Antimikrobielle egenskaber hos anaestetika og analgetika","volume":"161","author":"Bender AB","year":"1999","unstructured":"Bender AB, , Kristiansen EH. Antimikrobielle egenskaber hos anaestetika og analgetika. Ugeskr Laeger, 1999; 161:5814\u20135817.","journal-title":"Ugeskr Laeger"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-199907000-00001"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1621757"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-197903000-00015"},{"key":"e_1_3_1_7_2","first-page":"120","article-title":"Actividad bactericida del sevoflurano frente a Staphylococcus aureus, Pseudomonas aeruginosa y Escherichia coli [abstract]","volume":"27","author":"Mart\u00ednez M","year":"2009","unstructured":"Mart\u00ednez M, , Ger\u00f3nimo M, , Crespo MD. Actividad bactericida del sevoflurano frente a Staphylococcus aureus, Pseudomonas aeruginosa y Escherichia coli [abstract]. Enferm Infecc Microbiol Clin, 2009; 27 Especial Congreso:120\u2013121.","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.2823.233"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.2823.237"},{"key":"e_1_3_1_10_2","first-page":"46","article-title":"Sevoflurano como analg\u00e9sico local en herida isqu\u00e9mica de paciente cardi\u00f3pata con insuficiencia respiratoria secundaria a morfina","volume":"6","author":"Mart\u00ednez Monsalve A","year":"2011","unstructured":"Mart\u00ednez Monsalve A, , Ger\u00f3nimo Pardo M. Sevoflurano como analg\u00e9sico local en herida isqu\u00e9mica de paciente cardi\u00f3pata con insuficiencia respiratoria secundaria a morfina. Heridas Cicatrizaci\u00f3n, 2011; 6:46\u201349.","journal-title":"Heridas Cicatrizaci\u00f3n"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000121771.78755.F4"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03022057"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199936010-00002"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199651040-00009"}],"container-title":["Surgical Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/sur.2013.079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/sur.2013.079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/sur.2013.079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:18:40Z","timestamp":1777688320000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/sur.2013.079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,19]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12,1]]}},"alternative-id":["10.1089\/sur.2013.079"],"URL":"https:\/\/doi.org\/10.1089\/sur.2013.079","relation":{},"ISSN":["1096-2964","1557-8674"],"issn-type":[{"value":"1096-2964","type":"print"},{"value":"1557-8674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,19]]}}}