{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:08:43Z","timestamp":1779196123021,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Major resections for esophageal, gastric, hepatic, pancreatic, and colorectal cancer continue to be associated with a high peri-operative morbidity of up to 30%\u201340%. To a large extent, this morbidity is caused by infectious complications that add up to a considerable burden to patients and hospital costs. The objective of this large retrospective cross-sectional study was to determine independent patient and operation-related risk factors for infectious complications after major abdominal cancer operations to elucidate how infection rates can be reduced and improve health-care quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>\n                      In 1,389 cancer patients who underwent a major resection procedure between 2009 and 2013, infectious complications and their independent determinants were analyzed by multivariable logistic regression\n                      <jats:italic toggle=\"yes\">(<\/jats:italic>\n                      p\n                      <jats:italic toggle=\"yes\">&lt;<\/jats:italic>\n                      0.05\n                      <jats:italic toggle=\"yes\">)<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Male gender was a risk factor for infections in general, whereas patients \u226565\u2009y (odds ratio [OR] 1.75; p\u2009=\u20090.008), urinary tract infection (OR 0.51; p\u2009=\u20090.004), American Society of Anesthesiologists score (OR 1.55; p\u2009=\u20090.004), overall (OR 1.70; p\u2009=\u20090.037), vascular (OR 1.59; p\u2009=\u20090.020), and neurologic comorbidity (OR 2.22; p\u2009=\u20090.001) were associated significantly with pneumonia. Intra-abdominal drainage (OR 1.41; p\u2009=\u20090.024) and a duration of surgery of \u2265180\u2009min (OR 1.85; p\u2009=\u20090.001) were risk factors for surgical site infections. Total parenteral nutrition was significantly associated with intravascular catheter-induced infections (OR 18.09; p\u2009&lt;\u20090.001) and sepsis (OR 6.69; p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this study, several independent risk factors for infectious complications in major abdominal cancer operations were identified, providing opportunities for further reducing peri-operative infections. General awareness and focus on preventing infectious complications may have a significant impact on health-care outcomes and costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/sur.2016.033","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T15:20:02Z","timestamp":1470151202000},"page":"683-693","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Infectious Complications after Major Abdominal Cancer Surgery: In Search of Improvable Risk Factors"],"prefix":"10.1177","volume":"17","author":[{"given":"Linda C.","family":"Smit","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Microbiology and Infectious Diseases","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan J.","family":"Bruins","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology and Infectious Diseases","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gijs A.","family":"Patijn","sequence":"additional","affiliation":[{"name":"Department of Surgery, Isala, Zwolle, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gijs J.H.M.","family":"Ruijs","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology and Infectious Diseases","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,8,2]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-4354-3_8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2001.01782.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200210000-00001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-010-4419-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.140.3.278"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2001.1124"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.3.314"},{"key":"e_1_3_2_9_2","first-page":"698","article-title":"Adequate preoperative biliary drainage is determinative to decrease postoperative infectious complications after pancreaticoduodenectomy","volume":"57","author":"Lin SC","year":"2010","unstructured":"Lin SC, , Shan YS, , Lin PW. 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