{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:41:01Z","timestamp":1790959261600,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study was performed to investigate the combination of admission serum procalcitonin (PCT) and albumin (alb) concentrations as a diagnostic predictor for discriminating patients with nosocomial blood stream infection (BSI) among those with spontaneous intra-cerebral hemorrhage (ICH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective study on patients with ICH and hospital-acquired BSI. Clinical and microbiological data were compared in patients who experienced nosocomial BSI during a hospital stay and those who did not. Multivariable logistic regression analyses were used to identify independent risk factors for nosocomial BSI. A receiver operating characteristic (ROC) curve analysis was performed to compare the predictive accuracy of the albumin:PCT ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients with nosocomial BSI had lower albumin:PCT ratios than those without BSI (11.739 [3.192\u201338.452] versus 200.000 [40.634\u2013417.500]; p\u2009&lt;\u20090.001). Multivariable logistic regression analysis revealed that the albumin:PCT ratio (odds ratio [OR] 1.006; 95% confidence interval [CI] 1.002\u20131.011; p\u2009=\u20090.001], white blood cell count (OR 1.129; 95% CI 1.044\u20131.220; p\u2009=\u20090.002), and shock (OR 4.504; 95% CI 1.774\u201311.435; p\u2009=\u20090.002) were independent predictors of nosocomial BSI, allowing distinction of patients with the infection from those without. The area under the ROC curve for the albumin:PCT ratio was 0.830 (95% CI 0.768\u20130.892; p\u2009&lt;\u20090.001). The cut-off value of the albumin:PCT ratio was &lt;1.087 with a sensitivity of 90.6% and a specificity of 98.8%. In the subgroup of 85 patients with nosocomial BSI, the albumin:PCT ratio in patients with shock was lower than that in those without shock (7.154 [2.975\u201326.267] vs 28.000 [3.818\u201357.812]; p\u2009=\u20090.027).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The albumin:PCT ratio can be used as an early diagnostic predictor for nosocomial BSI in patients with ICH. Additionally, BSI patients with lower albumin:PCT ratios are more likely to experience shock. The albumin:PCT ratio is expected to be a rapid and low-cost tool for clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/sur.2018.260","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T16:39:56Z","timestamp":1559666396000},"page":"643-649","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Albumin\/Procalcitonin Ratio Is a Sensitive Early Marker of Nosocomial Blood Stream Infection in Patients with Intra-Cerebral Hemorrhage"],"prefix":"10.1177","volume":"20","author":[{"given":"Shuixiang","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai, China."},{"name":"Department of Emergency Care, Huashan Hospital Affiliated to Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, First Affiliated Hospital of Xiamen University, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441907"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000069"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70340-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091713"},{"key":"e_1_3_3_6_2","unstructured":"European Centre for Disease Prevention and Control. Healthcare-associated infections acquired in intensive care units: Annual epidemiological report 2016 [2014 data]. Surveillance Report 2017."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12195"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/515273"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01555-07"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181704"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP1MFYINQLECV2"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2016.160802"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2112"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm-2017-110838"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2017.307"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2005.11169"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2009.12.004"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8451-x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001278"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2017.05.007"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(07)60038-3"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0289"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.117655"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318264e3be"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.11.129"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3171\/2014.7.JNS132678"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.12.033"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.18.5.957a"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013627"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0538-5"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2125-7"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-04981-6_48"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-015-0504-2"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2012.121115"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1086\/600291"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060518766640"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011078"}],"container-title":["Surgical Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/sur.2018.260","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/sur.2018.260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/sur.2018.260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:24:19Z","timestamp":1777688659000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/sur.2018.260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,13]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,12,1]]}},"alternative-id":["10.1089\/sur.2018.260"],"URL":"https:\/\/doi.org\/10.1089\/sur.2018.260","relation":{},"ISSN":["1096-2964","1557-8674"],"issn-type":[{"value":"1096-2964","type":"print"},{"value":"1557-8674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,13]]}}}