{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:43:29Z","timestamp":1777934609739,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The identification of risk factors for superficial surgical site infections (SSSIs) associated with appendectomy is paramount in the management of patients with acute appendicitis (AA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study was a secondary data analysis from a prospective multi-center observational study. It included all consecutive hospitalized patients with AA who underwent appendectomy and were monitored for complications at 30 days after the intervention. A case-control approach was used to evaluate risk factors associated with the occurrence of SSSI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 2,667 patients, 156 (5.8%) developed an SSSI. The series included 1,449 males (54.3%) and 1,218 females with a median age of 29 years (interquartile range [IQR] 20\u201345 years). Antimicrobial therapy within the previous 30 days was reported by 170 patients (6.4%), and a C-reactive protein concentration (CRP) &gt;50\u2009mg\/L was observed in 609 (22.8%). A total of 960 patients (36.0%) underwent open surgery, 1,699 (63.7%) laparoscopic surgery, and 8 (0.3%) another surgical intervention. In 2,575 patients (95.6%), a pathological appendix was detected during the operation. In 776 patients (29.1%), an intra-operative abdominal drain (IAD) was placed; 125 patients (4.7%) were admitted to the intensive care unit. The median hospital length of stay was 3 days (IQR 2\u20135 days). The overall mortality rate was 0.11%. Multinomial logistic regression analysis of risk factors demonstrated that statistically significant risk factors independently associated with the occurrence of SSSIs were antimicrobial therapy within the previous 30 days, CRP &gt;50\u2009mg\/L, open surgical procedures, presence of IAD, and intra-operative findings of complex appendicitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Knowledge of five easily recognizable variables, assessable at hospital admission or as soon as the surgical intervention is concluded, might identify patients with a greater risk of developing an SSSI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/sur.2020.069","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T17:23:55Z","timestamp":1605633835000},"page":"227-233","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Epidemiology and Risk Factors for Superficial Surgical Site Infections after Appendectomy for Acute Appendicitis: A Secondary Data Analysis"],"prefix":"10.1177","volume":"22","author":[{"given":"Francesco M.","family":"Labricciosa","sequence":"first","affiliation":[{"name":"Global Alliance for Infections in Surgery, Vila Nova de Gaia, Portugal."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Sartelli","sequence":"additional","affiliation":[{"name":"Department of Surgery, Macerata Hospital, Macerata, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Barbadoro","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Public Health, Unit of Hygiene, Preventive Medicine and Public Health, Universit\u00e0 Politecnica delle Marche, Ancona, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian M.","family":"Abbo","sequence":"additional","affiliation":[{"name":"Infectious Disease University, Miami Miller School of Medicine and Jackson Health System, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Ansaloni","sequence":"additional","affiliation":[{"name":"General, Emergency and Trauma Surgery Department, Bufalini Hospital, Cesena, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Coccolini","sequence":"additional","affiliation":[{"name":"General, Emergency and Trauma Surgery Department, Pisa University Hospital, Pisa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Catena","sequence":"additional","affiliation":[{"name":"Emergency Surgery Department, Parma University Hospital, Parma, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002188"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-018-0179-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000324595"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749-7922-8-3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198411000-00002"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-5245-7"},{"key":"e_1_3_3_8_2","first-page":"CD001439","article-title":"Antibiotics versus placebo for prevention of postoperative infection after appendicectomy","volume":"3","author":"Andersen BR","year":"2005","unstructured":"Andersen BR, , Kallehave FL, , Andersen HK. 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