{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:36:22Z","timestamp":1792150582171,"version":"4.4.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Appropriate antimicrobial therapy for the management of intra-abdominal infection (IAI) continues to evolve based on available literature. The Study to Optimize Peritoneal Infection Therapy (STOP-IT) trial provided evidence to support four days of antibiotic agents in IAI post-source control but excluded patients with a planned re-laparotomy. This study aimed to determine the short- and long-term recurrent infection risk in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>This is a single-center, retrospective, observational study of adult patients admitted to a quaternary medical center between January 1, 2016, and August 1, 2022, with IAI requiring planned laparotomy. Patients were designated as receiving five or less days of antibiotic agents (short course) or more than five days (long course) after source control. The primary outcome was IAI recurrence within 30 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 104 patients who met inclusion criteria, 78 were included in analysis. Average age was 57\u2009\u00b1\u200913.3 years, 56% were male, 94% Caucasian, with a mean Acute Physiology and Chronic Health Evaluation (APACHE) II score of 17\u2009\u00b1\u20097.09. All other baseline characteristics and clinical severity markers were similar between the two groups. Regarding the primary outcome of IAI recurrence, there was no difference when comparing those who received short course versus those who received long course therapy (41.2% vs. 44.4%; p\u2009=\u20090.781). No differences were found between groups with respect to secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In patients admitted with IAI managed with planned re-laparotomy those who received short course antimicrobial therapy were not found to have an increase in IAI recurrence compared to those with longer courses of therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/sur.2023.255","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T11:20:16Z","timestamp":1708946416000},"page":"192-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Antibiotics for Patients With a Planned Re-Laparotomy for Intra-Abdominal Infection"],"prefix":"10.1177","volume":"25","author":[{"given":"Lauren J.","family":"Hochstetler","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Olney","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, Kentucky, USA."},{"name":"Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Bishop","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, Kentucky, USA."},{"name":"Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary D.","family":"Warriner","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Kentucky, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"VanHoose","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"Mynatt","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, Kentucky, USA."},{"name":"Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aric","family":"Schadler","sequence":"additional","affiliation":[{"name":"Kentucky Children's Hospital, Lexington, Kentucky, USA."},{"name":"University of Kentucky College of Pharmacy, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Parli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, Kentucky, USA."},{"name":"Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"issue":"21","key":"e_1_3_4_2_2","first-page":"2063","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus DC","year":"2013","unstructured":"Angus DC, , van der Poll T. Severe sepsis and septic shock. N Engl J Med, 2013; 369(21):2063; doi: 10.1056\/NEJMra1208623","journal-title":"N Engl J Med"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2011.039"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2012.077"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-021-00387-8"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2016.261"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2012.695455"},{"issue":"371","key":"e_1_3_4_8_2","first-page":"1","article-title":"2004 National Hospital Discharge Survey","volume":"4","author":"DeFrances CJ","year":"2006","unstructured":"DeFrances CJ, , Podgornik MN. 2004 National Hospital Discharge Survey. 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