{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:45:19Z","timestamp":1777934719416,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      : The optimal ampicillin\u2013sulbactam dosing regimen for carbapenem-susceptible\n                      <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                      isolates in critically ill trauma patients has not been clearly defined. One strategy to provide the adequate sulbactam dose includes high-dose continuous infusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case(s) Description:<\/jats:title>\n                    <jats:p>\n                      We present three cases of critically ill trauma patients with augmented renal clearance treated with high-dose ampicillin\u2013sulbactam through an intravenous continuous infusion for ventilator-associated pneumonia. All\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      isolates were susceptible to sulbactam with low minimum inhibitory concentrations. All achieved clinical cure at the end of therapy and no recurrent pneumonia was noted. No clinically substantial adverse effect attributable to ampicillin\u2013sulbactam therapy occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>\n                      There is limited evidence to endorse high-dose, continuous infusion ampicillin\u2013sulbactam for treatment of infections caused by carbapenem-susceptible\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      . This report presents three critically ill trauma patients with augmented renal clearance that achieved positive clinical outcomes with higher doses of ampicillin\u2013sulbactam administered through a continuous infusion.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/sur.2024.135","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T05:02:31Z","timestamp":1719982951000},"page":"553-557","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ampicillin\u2013Sulbactam for Carbapenem-Susceptible\n                    <i>Acinetobacter baumannii<\/i>\n                    Pneumonia: A Case for High-Dose, Continuous Infusion Dosing Strategy in the Trauma ICU"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-1450","authenticated-orcid":false,"given":"Bethany R.","family":"Shoulders","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Santevecchi","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena","family":"Venugopalan","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlin M.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad428"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/20499361231191877"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001211"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.12.017"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw353"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001387"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004667"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.08.021"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2008.04.002"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2020.06.004"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12232"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02534-19"},{"issue":"4","key":"e_1_3_4_15_2","article-title":"Sulbactam for treatment of carbapenem-resistant Acinetobacter baumannii","volume":"8","author":"Wangchinda W","year":"2023","unstructured":"Wangchinda W, , Pogue JM. Sulbactam for treatment of carbapenem-resistant Acinetobacter baumannii. Contagion, 2023; 8(4). https:\/\/www.contagionlive.com\/view\/sulbactam-for-treatment-of-carbapenem-resistant-acinetobacter-baumannii [Last accessed: April17, 2024].","journal-title":"Contagion"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac492.118"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.05.018"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00184-6"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00781-22"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000191"},{"key":"e_1_3_4_21_2","unstructured":"Ampicillin and sulbactam: Drug information. In UpToDate Connor RF .(Ed) Wolters Kluwer. Philadelphia [Last Accessed April 29 2024]."}],"container-title":["Surgical Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/sur.2024.135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/sur.2024.135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/sur.2024.135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:31:40Z","timestamp":1777689100000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/sur.2024.135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,9,1]]}},"alternative-id":["10.1089\/sur.2024.135"],"URL":"https:\/\/doi.org\/10.1089\/sur.2024.135","relation":{},"ISSN":["1096-2964","1557-8674"],"issn-type":[{"value":"1096-2964","type":"print"},{"value":"1557-8674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,1]]}}}