{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:45:06Z","timestamp":1777934706591,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Protocols for vancomycin de-escalation often rely on nasal swab testing for methicillin-resistant\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      (MRSA). However, in settings of hospital-wide universal MRSA decolonization with nasal mupirocin, these swabs may be unreliable, hindering de-escalation protocols. This study investigated vancomycin use and MRSA infection in trauma patients managed under each of these separate protocols.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective review compared patients admitted to a Level 1 trauma center during a time-period of MRSA swab-based vancomycin de-escalation (\u201cde-esc\u201d) with those admitted during a subsequent period of universal decolonization (and thus \u201cno de-esc\u201d). The primary outcome was total days of vancomycin per patient receiving vancomycin. Additional outcomes included a proportion of patients receiving a short course of vancomycin (&lt;3 d), overall vancomycin rates, and in-hospital MRSA infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 5,678 patients were evaluated, with 2,891 admitted during the \u201cde-esc\u201d period and 2,787 admitted during universal decolonization (\u201cno de-esc\u201d). There was no difference in the proportion of patients receiving vancomycin during the \u201cde-esc\u201d versus \u201cno de-esc\u201d protocols (7.2% [n = 208] vs. 6.5% [n = 181], p = 0.3). Among these patients, there was also no difference in either total days of vancomycin (5.3 d vs. 5.9 d, p = 0.3) or proportion receiving a short vancomycin course (33% vs. 29%, p = 0.5). There were 56 total patients with MRSA infections, with no difference between the two time periods (1.1% vs. 0.7%, p = 0.07).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Despite concerns that a hospital-wide MRSA universal decolonization policy would hinder nasal swab-based vancomycin de-escalation, both vancomycin use and MRSA infection rates remained the same during the two time periods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/sur.2024.280","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T12:25:51Z","timestamp":1743769551000},"page":"435-440","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Competing Interests: Vancomycin Use in Trauma Patients is Similar During Methicillin-Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    Nasal Swab Based De-Escalation and Universal Mupirocin Decolonization Protocols"],"prefix":"10.1177","volume":"26","author":[{"given":"Elizabeth D.","family":"Krebs","sequence":"first","affiliation":[{"name":"Division of Acute Care Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayan","family":"Rakhit","sequence":"additional","affiliation":[{"name":"Division of Acute Care Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer R.","family":"Beavers","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne","family":"Atchison","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-6398","authenticated-orcid":false,"given":"Robel T.","family":"Beyene","sequence":"additional","affiliation":[{"name":"Division of Acute Care Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/345476"},{"issue":"1","key":"e_1_3_4_3_2","first-page":"102","article-title":"The incidence and complications of methicillin-resistant Staphylococcus aureus in a community Level I trauma center","volume":"67","author":"Cook A","year":"2009","unstructured":"Cook A, , Berne J, , Norwood S. The incidence and complications of methicillin-resistant Staphylococcus aureus in a community Level I trauma center. 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