{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:04:24Z","timestamp":1779775464572,"version":"3.53.1"},"reference-count":24,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this study was to describe the clinical and microbiologic characteristics of adult patients with HIV infection and splenomegaly treated with splenectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective study, including patients with the diagnosis of HIV and splenomegaly treated with splenectomy between 2005 and 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We included 20 patients with a mean age of 36 years (\u00b12), with a predominance of males (n = 18). Some patients had more than one condition associated with splenomegaly. The following were considered as the indication for splenectomy: Splenic abscesses in 13 (65%), refractory thrombocytopenia in 9 (45%), symptomatic splenomegaly in 5 (25%), and splenic lymphoma in 1 (5%). After operation, spleen samples were sent for microbiology culture, displaying the invasion of bacteria in 11 (55%), fungi in 8 (40%), and viruses in 8 (40%). When evaluating the indications for splenectomy between groups, splenic abscesses were more present in those patients without active treatment (83% vs. 38%, p = 0.035), whereas symptomatic splenomegaly presented more frequently in those with active antiretroviral therapy (ART; 63% vs. 0%, p = 0.004).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The cornerstone of treatment for patients with splenomegaly should initially focus on adherence to ART and addressing the underlying cause. However, when the condition is refractory splenectomy may be indicated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/sur.2025.003","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T12:09:13Z","timestamp":1745323753000},"page":"561-566","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Splenectomy for the Treatment of Splenomegaly in People Living with HIV: An Uncommon Complication"],"prefix":"10.1177","volume":"26","author":[{"given":"Pablo","family":"Gomes-da Silva de Rosenzweig","sequence":"first","affiliation":[{"name":"Experimental Lung Transplant Laboratory, Instituto Nacional de Enfermedades Respiratorias \u201cDr Ismael Cos\u00edo Villegas\u201d, Mexico City, Mexico."},{"name":"Postgraduate Department, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5168-7240","authenticated-orcid":false,"given":"Oscar Mario","family":"Delgado-Casillas","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Instituto Nacional de Enfermedades Respiratorias \u201cDr Ismael Cos\u00edo Villegas\u201d, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"V\u00e1zquez-Minero","sequence":"additional","affiliation":[{"name":"Postgraduate Department, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Stanley","family":"Vega-Barrientos","sequence":"additional","affiliation":[{"name":"Medical Direction, Instituto Nacional de Enfermedades Respiratorias \u201cDr Ismael Cos\u00edo Villegas\u201d, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"issue":"5","key":"e_1_3_5_2_2","first-page":"357","article-title":"Caracter\u00edsticas cl\u00ednicas y evoluci\u00f3n de pacientes con SIDA y dolor abdominal agudo","volume":"141","author":"Ferat-Osorio E","year":"2005","unstructured":"Ferat-Osorio E, , Guzm\u00e1n-Valdivia GG, , Rosales BL, et al. Caracter\u00edsticas cl\u00ednicas y evoluci\u00f3n de pacientes con SIDA y dolor abdominal agudo. Gac. M\u00e9d. M\u00e9x, 2005; 141(5):357\u2013362.","journal-title":"Gac. M\u00e9d. M\u00e9x"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-017-0387-9"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/313816"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2018.04.009"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2020.0266"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2017.11.011"},{"issue":"3","key":"e_1_3_5_8_2","first-page":"271","article-title":"Splenomegaly: Diagnosis and management in adults","volume":"104","author":"Aldulaimi S","year":"2021","unstructured":"Aldulaimi S, , Mendez AM. Splenomegaly: Diagnosis and management in adults. 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