{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:17:19Z","timestamp":1784373439658,"version":"3.55.0"},"reference-count":77,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part A"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>\n                    Following complete nerve transection, entubulation of the nerve stumps helps guide axons to reconnect distally. In this study, a biodegradable and noncytotoxic tyrosine-derived polycarbonate terpolymer composed of 89.5\u2009mol% desaminotyrosyl tyrosine ethyl ester (DTE), 10\u2009mol% desaminotyrosyl tyrosine (DT), and 0.5\u2009mol% poly(ethylene glycol) (PEG, molecular weight [Mw]=1\u2009kDa) [designated as E10-0.5(1K)] was used to fabricate conduits for peripheral nerve regeneration. These conduits were evaluated against commercially available nonporous polyethylene (PE) tubes. The two materials are characterized\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    for differences in surface properties, and the conduits are then evaluated\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    in a critical-sized nerve defect in the mouse femoral nerve model. Conduits were fabricated from E10-0.5(1K) in both porous [P-E10-0.5(1K)] and nonporous [NP-E10-0.5(1K)] configurations. The results illustrate that adsorption of laminin, fibronectin, and collagen type I was enhanced on E10-0.5(1K) compared to PE. In addition,\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    the E10-0.5(1K) conduits improved functional recovery over PE conduits, producing regenerated nerves with a fivefold increase in the number of axons, and an eightfold increase in the percentage of myelinated axons. These increases were observed for both P-E10-0.5(1K) and NP-E10-0.5(1K) after 15 weeks. When conduits were removed at 7 or 14 days following implantation, an increase in Schwann cell proteins and fibrin matrix formation was observed in E10-0.5(1K) conduits over PE conduits. These results indicate that E10-0.5(1K) is a pro-regenerative material for peripheral nerves and that the porosity of P-E10-0.5(1K) conduits was inconsequential in this model of nerve injury.\n                  <\/jats:p>","DOI":"10.1089\/ten.tea.2013.0092","type":"journal-article","created":{"date-parts":[[2013,9,7]],"date-time":"2013-09-07T00:55:17Z","timestamp":1378515317000},"page":"518-528","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Enhanced Femoral Nerve Regeneration After Tubulization with a Tyrosine-Derived Polycarbonate Terpolymer: Effects of Protein Adsorption and Independence of Conduit Porosity"],"prefix":"10.1177","volume":"20","author":[{"given":"Mindy","family":"Ezra","sequence":"first","affiliation":[{"name":"The State University of New Jersey"},{"name":"The State University of New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Bushman","sequence":"additional","affiliation":[{"name":"The State University of New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shreiber","sequence":"additional","affiliation":[{"name":"The State University of New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melitta","family":"Schachner","sequence":"additional","affiliation":[{"name":"The State University of New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Kohn","sequence":"additional","affiliation":[{"name":"The State University of New Jersey"},{"name":"The State University of New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","unstructured":"Noble J. 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