{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:49:19Z","timestamp":1777938559550,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"5-6","license":[{"start":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T00:00:00Z","timestamp":1420588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part A"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>\n                    The present study employed nerve guidance conduits (NGCs) only, which were made of small intestine submucosa (SIS) and poly(caprolactone-\n                    <jats:italic toggle=\"yes\">co<\/jats:italic>\n                    -lactide) (PCLA) to promote nerve regeneration in a peripheral nerve injury (\n                    <jats:sc>PNI<\/jats:sc>\n                    ) model with nerve defects of 15\u2009mm. The SIS- and PCLA-NGCs were easily prepared by rolling of a SIS sheet and a bioplotter using PCLA, respectively. The prepared SIS- and PCLA-NGCs fulfilled the general requirement for use as artificial peripheral NGCs such as easy fabrication, reproducibility for mass production, suturability, sterilizability, wettability, and proper mechanical properties to resist collapsing when applied to\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    implantation. The SIS- and PCLA-NGCs appeared to be well integrated into the host sciatic nerve without causing dislocations and serious inflammation. All NGCs stably maintained their NGC shape for 8 weeks without collapsing, which matched well with the nerve regeneration rate. Staining of the NGCs in the longitudinal direction showed that the regenerated nerves grew successfully from the SIS- and PCLA-NGCs through the sciatic nerve-injured gap and connected from the proximal to distal direction along the NGC axis. SIS-NGCs exhibited a higher nerve regeneration rate than PCLA-NGCs. Collectively, our results indicate that SIS- and PCLA-NGCs induced nerve regeneration in a PNI model, a finding that has significant implications in the future with regard to the feasibility of clinical nerve regeneration with SIS- and PCLA-NGCs prepared through an easy fabrication method using promising biomaterials.\n                  <\/jats:p>","DOI":"10.1089\/ten.tea.2014.0165","type":"journal-article","created":{"date-parts":[[2014,11,30]],"date-time":"2014-11-30T07:24:59Z","timestamp":1417332299000},"page":"1142-1151","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of Small Intestine Submucosa and Poly(caprolactone-\n                    <i>co<\/i>\n                    -lactide) Conduits for Peripheral Nerve Regeneration"],"prefix":"10.1177","volume":"21","author":[{"given":"Sun Woo","family":"Shim","sequence":"first","affiliation":[{"name":"Ajou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doo Yeon","family":"Kwon","sequence":"additional","affiliation":[{"name":"Ajou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bit Na","family":"Lee","sequence":"additional","affiliation":[{"name":"Ajou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Seon","family":"Kwon","sequence":"additional","affiliation":[{"name":"Ajou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Ajou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea Institute of Machinery and Materials"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Ajou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Catholic University of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Woog","family":"Shin","sequence":"additional","affiliation":[{"name":"Inje University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai Bang","family":"Lee","sequence":"additional","affiliation":[{"name":"Ajou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Doo","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea Institute of Machinery and Materials"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Ajou University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,1,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2005.3278"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/145749690809700407"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2008.07.018"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200202000-00022"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2007.06.005"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2007-00366"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1333316"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v39.i2.20"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.08.074"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0jm04335d"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.07.056"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.04.018"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2011.0498"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.03.043"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0122"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2174\/2211542011201010041"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2012.02.004"},{"key":"e_1_3_3_19_2","first-page":"173","article-title":"Fabrication and characterization of nerve growth factor-immobilized asymmetrically porous PDOCL\/Pluronic F127 nerve guide conduit","volume":"8","author":"Park S.C.","year":"2011","unstructured":"Park S.C., , Oh S.H., , and Lee J.H. 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