{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:10:14Z","timestamp":1783775414538,"version":"3.55.0"},"reference-count":86,"publisher":"SAGE Publications","issue":"17-18","license":[{"start":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T00:00:00Z","timestamp":1525824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part A"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>\n                    Suturing peripheral nerve transections is the predominant therapeutic strategy for nerve repair. However, the use of sutures leads to scar tissue formation, hinders nerve regeneration, and prevents functional recovery. Fibrin-based adhesives have been widely used for nerve reconstruction, but their limited adhesive and mechanical strength and inability to promote nerve regeneration hamper their utility as a stand-alone intervention. To overcome these challenges, we engineered composite hydrogels that are neurosupportive and possess strong tissue adhesion. These composites were synthesized by photocrosslinking two naturally derived polymers, gelatin-methacryloyl (GelMA) and methacryloyl-substituted tropoelastin (MeTro). The engineered materials exhibited tunable mechanical properties by varying the GelMA\/MeTro ratio. In addition, GelMA\/MeTro hydrogels exhibited 15-fold higher adhesive strength to nerve tissue\n                    <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                    compared to fibrin control. Furthermore, the composites were shown to support Schwann cell (SC) viability and proliferation, as well as neurite extension and glial cell participation\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    , which are essential cellular components for nerve regeneration. Finally, subcutaneously implanted GelMA\/MeTro hydrogels exhibited slower degradation\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    compared with pure GelMA, indicating its potential to support the growth of slowly regenerating nerves. Thus, GelMA\/MeTro composites may be used as clinically relevant biomaterials to regenerate nerves and reduce the need for microsurgical suturing during nerve reconstruction.\n                  <\/jats:p>","DOI":"10.1089\/ten.tea.2017.0502","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T03:07:12Z","timestamp":1522120032000},"page":"1393-1405","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":95,"title":["Photocrosslinkable Gelatin\/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair"],"prefix":"10.1177","volume":"24","author":[{"given":"Jonathan R.","family":"Soucy","sequence":"first","affiliation":[{"name":"Northeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Shirzaei Sani","sequence":"additional","affiliation":[{"name":"Northeastern 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