{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:52:03Z","timestamp":1777938723703,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"23-24","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part A"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n                    This study investigated bone regeneration in the femoral neck canal of osteoporotic rats using a novel animal model. A calcium sulphate (CS)\/hydroxyapatite (HA) carrier was used to deliver a bisphosphonate, zoledronic acid (ZA), locally, with or without added recombinant human bone morphogenic protein-2 (rhBMP-2). Twenty-eight-week-old ovariectomized Sprague\u2013Dawley rats were used. A 1\u2009mm diameter and 8\u2009mm long defect was created in the femoral neck by drilling from the lateral cortex in the axis of the femoral neck, leaving the surrounding cortex intact. Three treatment groups and one control group were used: (1) CS\/HA alone, (2) CS\/HA + ZA (10\u2009\u03bcg) (3) CS\/HA + ZA (10\u2009\u03bcg) + rhBMP-2 (4\u2009\u03bcg), and (4) empty defect (control). The bone formation was assessed at 4 weeks post surgery using\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    micro computed tomography (micro-CT). At 8 weeks post surgery, the animals were sacrificed, and both defect and contralateral femurs were subjected to micro-CT, mechanical testing, and histology. Micro-CT results showed that the combination of CS\/HA with ZA or ZA + rhBMP-2 increased the bone formation in the defect when compared to the other groups and to the contralateral hips. Evidence of new dense bone formation in CS\/HA + ZA and CS\/HA + ZA + rhBMP-2 groups was seen histologically. Mechanical testing results showed no differences in the load to fracture between the treatments in either of the treated or contralateral legs. The CS\/HA biomaterial can be used as a carrier for ZA and rhBMP-2 to regenerate bone in the femoral neck canal of osteoporotic rats.\n                  <\/jats:p>","DOI":"10.1089\/ten.tea.2018.0075","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T08:27:35Z","timestamp":1527841655000},"page":"1753-1764","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Calcium Sulphate\/Hydroxyapatite Carrier for Bone Formation in the Femoral Neck of Osteoporotic Rats"],"prefix":"10.1177","volume":"24","author":[{"given":"Aurimas","family":"\u0160irka","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology, Lithuanian University of Health Sciences, Kaunas, Lithuania."},{"name":"Department of Clinical Sciences Lund, Orthopedics, Faculty of Medicine; Lund University, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak Bushan","family":"Raina","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Orthopedics, Faculty of Medicine; Lund University, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Isaksson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Orthopedics, Faculty of Medicine; Lund University, Lund, Sweden."},{"name":"Department of Biomedical Engineering; Lund University, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Elizabeth","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Orthopedics, Faculty of Medicine; Lund University, Lund, Sweden."},{"name":"School of Engineering, University of Glasgow, Glasgow, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredas","family":"Smailys","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Lithuanian University of Health Sciences, Kaunas, Lithuania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Uttar Pradesh, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0160ar\u016bnas","family":"Tarasevi\u010dius","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Lithuanian University of Health Sciences, Kaunas, Lithuania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"T\u00e4gil","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Orthopedics, Faculty of Medicine; Lund University, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Lidgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Orthopedics, Faculty of Medicine; Lund University, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-48"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-013-0136-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51110.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1586-z"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067312"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074941"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1429-y"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4009-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1549-6"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3698.893"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.05.061"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.06.008"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199908)46:2<193::AID-JBM8>3.0.CO;2-1"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.01732"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00358-6"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep26033"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.06.030"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0828-3"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31524"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2015.11.002"},{"key":"e_1_3_3_22_2","first-page":"10775","article-title":"Gelatin-modified bone substitute with bioactive molecules enhance cellular interactions and bone regeneration.","volume":"8","author":"Teotia A.K.","year":"2016","unstructured":"Teotia A.K., , Gupta A., , Raina D.B., , Lidgren L., , and Kumar A. 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