{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:53:16Z","timestamp":1777938796170,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part A"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>In dental clinical practice, systemic steroids are often applied at the end of implant surgeries to reduce postsurgical inflammation (tissue swelling, etc.) and to reduce patient discomfort. However, the use of systemic steroids is associated with generalized catabolic effects and with a temporarily reduced immunological competence. We hypothesize that by applying locally anticytokine antibodies (antitumor necrosis factor alpha and anti-interleukin-1 beta) together with a bioactive osteogenic implant at the time of the surgical intervention for the placement of a construct, we will be able to achieve the same beneficial effects as those using systemic steroids but are able to avoid the generalized antianabolic effects and the reduced immunocompetence effects, associated with the systemic use of steroids. In an adult rat model, a collagen sponge, soaked with the osteogenic agent bone morphogenetic protein-2, was used as an example for a bioactive implant material and was surgically placed subcutaneously. In the acute inflammatory phase after implantation (2 days after surgery) we investigated the local inflammatory tissue response, and 18 days postsurgically the efficiency of local osteogenesis (to assess possible antianabolic effects). We found that the negative control groups, treated postsurgically with systemic steroids, showed a significant suppression of both the inflammatory response and the osteogenetic activity, that is, they were associated with significant general antianabolic effects, even when steroids were used only at a low dose level. The local anticytokine treatment, however, was able to significantly enhance new bone formation activity, that is, the anabolic activity, over positive control values with BMP-2 only. However, the anticytokine treatment was unable to reduce the local inflammatory and swelling responses.<\/jats:p>","DOI":"10.1089\/ten.tea.2020.0067","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:29:43Z","timestamp":1592180983000},"page":"177-186","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Anticytokine Activity Enhances Osteogenesis of Bioactive Implants"],"prefix":"10.1177","volume":"27","author":[{"given":"Fan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Stomatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Human Movement Sciences, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hairong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis, Inselspital Bern University Hospital, Bern, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije University Amsterdam, Amsterdam, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Lippuner","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis, Inselspital Bern University Hospital, Bern, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst B.","family":"Hunziker","sequence":"additional","affiliation":[{"name":"Departments of Osteoporosis and Orthopedic Surgery, Inselspital Bern University Hospital, Bern, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.08.012"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/ejd.ejd_249_17"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2009.0255"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4806759"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2015.145"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12287"},{"key":"e_1_3_3_8_2","first-page":"E129","article-title":"Clinical comparative study of the effectiveness of two dosages of Dexamethasone to control postoperative swelling, trismus and pain after the surgical extraction of mandibular impacted third molars","volume":"13","author":"Laureano Filho J.R.","year":"2008","unstructured":"Laureano Filho J.R., , Maurette P.E., , Allais M., , Cotinho M., , and Fernandes C. 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