{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:04:34Z","timestamp":1781168674123,"version":"3.54.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"9-10","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part A"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>\n                    Microtia is a congenital malformation of the auricle. The conventional therapy for microtia is reconstruction of the auricle by using the patient's own costal cartilage. Because it is invasive to harvest costal cartilages, less invasive ways for auricular reconstruction need to be established. Recent reports have indicated a new method for the production of cartilaginous particles from human induced pluripotent stem cells. To adopt this method to create an auricular-shaped regenerative cartilage, a novel scaffold with the property of a three-dimensional shape memory was created. A scaffold with a three-dimensional shape of auricular frames composed of a helix and an antihelix, which was designed to mimic an auricular framework carved from autologous costal cartilage and transplanted in auricular reconstruction, was prepared, filled with cartilaginous particles, and subcutaneously transplanted in nude rats. The auricular-shaped regenerative cartilage maintained the given shape and cartilage features\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    for 1 year. Our findings suggest a novel approach for auricular reconstruction.\n                  <\/jats:p>","DOI":"10.1089\/ten.tea.2020.0106","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T01:08:11Z","timestamp":1599181691000},"page":"604-617","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Ear Cartilage Reconstruction Combining Induced Pluripotent Stem Cell-Derived Cartilage and Three-Dimensional Shape-Memory Scaffold"],"prefix":"10.1177","volume":"27","author":[{"given":"Sakura","family":"Uto","sequence":"first","affiliation":[{"name":"Division of Tissue Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhiko","family":"Hikita","sequence":"additional","affiliation":[{"name":"Division of Tissue Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Division of Tissue Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Mori","sequence":"additional","affiliation":[{"name":"Bone and Cartilage Regenerative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Yano","sequence":"additional","affiliation":[{"name":"Bone and Cartilage Regenerative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Ohba","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Takato","sequence":"additional","affiliation":[{"name":"Department of Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan."},{"name":"JR Tokyo General Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Division of Tissue Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan."},{"name":"Department of Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X640574"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.02.028"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32509"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2008.0154"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199708000-00001"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000164388.33965.4e"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2017.09.001"},{"key":"e_1_3_5_9_2","first-page":"479","article-title":"Development of implant - type tissue - engineered cartilage for cleft lip - nose deformity","volume":"73","author":"Takato T.","year":"2015","unstructured":"Takato T., , Fujihara Y., , and Hoshi K. 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Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements, J Mater Sci Mater Med, 29, 56, 2018.","journal-title":"J Mater Sci Mater Med"},{"key":"e_1_3_5_24_2","first-page":"57","article-title":"Development of human head simulation model for predicting probability of head injuries","volume":"59","author":"Watanabe R.","year":"2013","unstructured":"Watanabe R., , Ito M., , Namba Y., , and Kishimoto T. Development of human head simulation model for predicting probability of head injuries. 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