{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:07:50Z","timestamp":1784686070364,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part A"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>\n                    Characterizing the release profile for materials-directed local delivery of bioactive molecules and its effect on bone regeneration is an important step to improve our understanding of, and ability to optimize, the bone healing response. This study examined the local delivery of parathyroid hormone (PTH) using a thiol-ene hydrogel embedded in a porous poly(propylene fumarate) (PPF) scaffold for bone regeneration applications. The aim of this study was to characterize the degradation-controlled\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    release kinetics of PTH from the thiol-ene hydrogels,\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    hydrogel degradation in a subcutaneous implant model, and bone healing in a rat critical size bone defect. Tethering PTH to the hydrogel matrix eliminated the early timepoint burst release that was observed in previous\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    work where PTH was free to diffuse out of the matrix. Only 8% of the tethered PTH was released from the hydrogel during the first 2 weeks, but by day 21, 80% of the PTH was released, and complete release was achieved by day 28.\n                    <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                    implantation revealed that complete degradation of the hydrogel alone occurred by day 21; however, when incorporated in a three-dimensional printed osteoconductive PPF scaffold, the hydrogel persisted for &gt;56 days. Treatment of bone defects with the composite thiol-ene hydrogel\u2013PPF scaffold, delivering either 3 or 10\u2009\u03bcg of tethered PTH 1-84, was found to increase bridging of critical size bone defects, whereas treatment with 30\u2009\u03bcg of tethered PTH resulted in less bone ingrowth into the defect area. Continued development of this biomaterial delivery system for PTH could lead to improved therapies for treatment of nonunion fractures and critical size bone defects.\n                  <\/jats:p>","DOI":"10.1089\/ten.tea.2020.0119","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T01:01:08Z","timestamp":1593738068000},"page":"246-255","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Impact of Release Kinetics on Efficacy of Locally Delivered Parathyroid Hormone for Bone Regeneration Applications"],"prefix":"10.1177","volume":"27","author":[{"given":"Samantha J.","family":"Wojda","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Marozas","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi S.","family":"Anseth","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Yaszemski","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth W.","family":"Donahue","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts, USA."},{"name":"Department of Mechanical Engineering, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0446"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24075"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.11.1932"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00312-2"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650070110"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080910"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/000164700317362271"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200405000-00014"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2017.07.019"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/10837450802282488"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.05.034"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-110-2-506"},{"key":"e_1_3_4_14_2","first-page":"477","article-title":"Comparison of the effects of intermittent and continuous administration of human parathyroid hormone(1-34) on rat bone","volume":"16","author":"Uzawa T.","year":"1995","unstructured":"Uzawa T., , Hori M., , Ejiri S., , and Ozawa H. Comparison of the effects of intermittent and continuous administration of human parathyroid hormone(1-34) on rat bone. Bone, 16, 477, 1995.","journal-title":"Bone"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040302"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2012.11.005"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-4-930"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24502"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01342.x"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.12.023"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.2007.00890.x"},{"key":"e_1_3_4_22_2","first-page":"258","article-title":"Bone regeneration using a synthetic matrix containing a parathyroid hormone peptide combined with a grafting material","volume":"22","author":"Jung R.E.","year":"2007","unstructured":"Jung R.E., , Hammerle C.H.F., , Kokovic V., , and Weber F.E. Bone regeneration using a synthetic matrix containing a parathyroid hormone peptide combined with a grafting material. Int J Oral Maxillofac Implants, 22, 258, 2007.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.08.040"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1201\/9780849378898"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02185"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.05.003"},{"key":"e_1_3_4_27_2","volume-title":"Mechanical Engineering","author":"Gray S.K.","year":"2012","unstructured":"Gray S.K. Treatment of osteoporosis in a mouse model of Duchenne muscular dystrophy using black bear parathyroid hormone [Master's thesis]. Mechanical Engineering, Michigan Technological University, Houghton, MI, 2012."},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm060834v"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.12.024"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.08.055"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200901808"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2003.12.003"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.06.009"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12532"}],"container-title":["Tissue Engineering Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ten.tea.2020.0119","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ten.tea.2020.0119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ten.tea.2020.0119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:51:56Z","timestamp":1777697516000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/ten.tea.2020.0119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":33,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1089\/ten.tea.2020.0119"],"URL":"https:\/\/doi.org\/10.1089\/ten.tea.2020.0119","relation":{},"ISSN":["1937-3341","1937-335X"],"issn-type":[{"value":"1937-3341","type":"print"},{"value":"1937-335X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}