{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:30:03Z","timestamp":1782603003428,"version":"3.54.5"},"reference-count":39,"publisher":"SAGE Publications","issue":"9-10","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part A"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>\n                    Octacalcium phosphate and collagen composite (OCPcol) demonstrated superior bone regeneration and has been commercialized recently in Japan. Teriparatide (TPTD) is a bioactive recombinant form of parathyroid hormone that is approved for osteoporosis treatment. Because mandibular bone reconstruction after segmental resection is a key clinical problem, it was examined whether single-dose local administration of OCPcol with TPTD can affect recovery after this procedure. OCPcol was prepared, and a commercially available hydroxyapatite and collagen composite (HAPcol) was used as a control. A 15\u2009mm length segmental bone defect was made in the mandibular region of male beagle dogs. The experimental animals were divided in four groups. OCPcol treated with TPTD (OCPcol + TPTD), OCPcol, HAPcol treated with TPTD (HAPcol + TPTD), or HAPcol was implanted into the defect. The radiopaque areas of the implanted site were measured and statistically analyzed, and histological examination was performed after 6 months. The value of radiopaque area in total region of OCPcol + TPTD was highest (90.8\u2009\u00b1\u20097.3\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    ), followed in order by OCPcol (49.3\u2009\u00b1\u200921.8\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    ), HAPcol + TPTD (10.6\u2009\u00b1\u20092.3\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    ), and HAPcol (6.4\u2009\u00b1\u20092.3\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    ), and that of OCPcol + TPTD was significantly higher than that of HAPcol + TPTD or HAPcol. All segmented mandibles of OCPcol + TPTD and a part of those of OCPcol were bridged with newly formed bone, whereas no bone bridges were observed in HAPcol + TPTD or HAPcol. These results suggested that OCPcol treated with TPTD enabled bone reconstruction after segmental mandibular resection more than other three groups.\n                  <\/jats:p>","DOI":"10.1089\/ten.tea.2020.0150","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T02:05:35Z","timestamp":1597629935000},"page":"561-571","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Segmental Bone Reconstruction by Octacalcium Phosphate Collagen Composites with Teriparatide"],"prefix":"10.1177","volume":"27","author":[{"given":"Keiko","family":"Matsui","sequence":"first","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kawai","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, Morioka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Ezoe","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Bone Regenerative Engineering Laboratory, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kamakura","sequence":"additional","affiliation":[{"name":"Bone Regenerative Engineering Laboratory, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-017-2775-y"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000256065.62382.89"},{"key":"e_1_3_4_4_2","first-page":"Ra107","article-title":"Methods of reconstruction for bone defect after tumor excision: a review of alternatives","volume":"14","author":"Nishida J.","year":"2008","unstructured":"Nishida J., , and Shimamura T. 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