{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:21:04Z","timestamp":1793215264473,"version":"4.5.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part A"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>\n                    Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disorder affecting the temporomandibular joint (TMJ), marked by persistent inflammation and structural damage to the joint. Only symptomatic treatment is available for managing TMJOA. Human umbilical cord mesenchymal stem cells (hUC-MSCs) show potential for treating TMJOA via their immune-modulating actions in the disease area. In addition, stimulation of inflammatory cytokines such as interferon-gamma in hUC-MSCs improves the therapeutic activity of na\u00efve stem cells. Emerging evidence indicates that macrophages play significant roles in regulating joint inflammation through diverse secreted mediators in the pathogenesis of TMJOA. This study was conducted to evaluate the effects of inflammatory cytokine-stimulated hUC-MSCs in repairing TMJOA-induced cartilage lesions and the role of macrophages in the disease. Our\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    data showed that stimulated hUC-MSCs induce M2 polarization of macrophages and enhance the expression of anti-inflammatory molecules. These effects were subsequently validated\n                    <jats:italic toggle=\"yes\">in\u00a0vivo<\/jats:italic>\n                    . In a rat model of TMJOA, stimulated hUC-MSCs ameliorated inflammation and increased M2 macrophages ratio. Our results indicate that hUC-MSCs stimulated by inflammatory cytokines modulate the activation of M2 macrophages, thereby shifting the local osteoarthritis microenvironment toward a prochondrogenic state and facilitating cartilage repair in inflammatory conditions. Stimulating hUC-MSCs with inflammatory cytokines could potentially offer an effective therapeutic approach for TMJOA, with macrophages playing a pivotal role in immune modulation.\n                  <\/jats:p>","DOI":"10.1089\/ten.tea.2023.0370","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T09:45:52Z","timestamp":1716543952000},"page":"351-360","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Primed IFN-\u03b3-Umbilical Cord Stem Cells Ameliorate Temporomandibular Joint Osteoarthritis"],"prefix":"10.1177","volume":"31","author":[{"given":"Yerin","family":"Kim","sequence":"first","affiliation":[{"name":"AMIST, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Asan Institute for Life Science, Asan Medical Center, Asan Medical Institute of Convergence Science and Technology, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Yeon","family":"Yun","sequence":"additional","affiliation":[{"name":"AMIST, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8888-1719","authenticated-orcid":false,"given":"Bu-Kyu","family":"Lee","sequence":"additional","affiliation":[{"name":"AMIST, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea."},{"name":"Asan Institute for Life Science, Asan Medical Center, Asan Medical Institute of Convergence Science and Technology, Seoul, Korea."},{"name":"Department of Oral and Maxillofacial Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345221100179"},{"issue":"6","key":"e_1_3_7_3_2","first-page":"378","article-title":"Diagnosis and treatment of temporomandibular disorders","volume":"91","author":"Gauer RL","year":"2015","unstructured":"Gauer RL, , Semidey MJ. Diagnosis and treatment of temporomandibular disorders. 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Imbalance of M1\/M2 macrophages is linked to severity level of knee osteoarthritis. Exp Ther Med, 2018; 16(6):5009\u20135014; doi: 10.3892\/etm.2018.6852","journal-title":"Exp Ther Med"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.09.024"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/816460"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1447-y"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep38308"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00111"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08398-4"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09827-5"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2023.0066"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(99)00136-5"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep16244"},{"issue":"1","key":"e_1_3_7_33_2","first-page":"261","article-title":"Macrophages in osteoarthritis: Pathophysiology and therapeutics","volume":"12","author":"Chen Y","year":"2020","unstructured":"Chen Y, , Jiang W, , Yong H, et al. Macrophages in osteoarthritis: Pathophysiology and therapeutics. 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Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages. J Nanobiotechnology, 2022; 20(1):20\u201338; doi: 10.1186\/s12951-021-01236-1","journal-title":"J Nanobiotechnology"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2014.02.005"}],"container-title":["Tissue Engineering Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ten.tea.2023.0370","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ten.tea.2023.0370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ten.tea.2023.0370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:55:06Z","timestamp":1777697706000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/ten.tea.2023.0370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":41,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1089\/ten.tea.2023.0370"],"URL":"https:\/\/doi.org\/10.1089\/ten.tea.2023.0370","relation":{},"ISSN":["1937-3341","1937-335X"],"issn-type":[{"value":"1937-3341","type":"print"},{"value":"1937-335X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]}}}