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Lymphedema significantly reduces quality of life of patients on a physical, mental, social, and economic basis. Current therapeutic approaches in treatment of lymphatic disease are limited. Over the last decades, great progress has been made in the development of therapeutic strategies to enhance vascular regeneration. These solutions to treat vascular disease may also be applicable in the treatment of lymphatic diseases. Comparison of the organogenic process and biological organization of the vascular and lymphatic systems and studies in the regulatory mechanisms involved in lymphangiogenesis and angiogenesis show many common features. In this study, we address the similarities between both transport systems, and focus in depth on the biology of lymphatic development. Based on the current advances in vascular regeneration, we propose different strategies for lymphatic tissue engineering that may be used for treatment of primary and secondary lymphedema.<\/jats:p>","DOI":"10.1089\/ten.teb.2015.0231","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T10:36:15Z","timestamp":1437647775000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Lymphatic Vascular Regeneration: The Next Step in Tissue Engineering"],"prefix":"10.1177","volume":"22","author":[{"given":"Eline","family":"Huethorst","sequence":"first","affiliation":[{"name":"University Medical Center Utrecht","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merle M.","family":"Krebber","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht","place":["The 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