{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:46:52Z","timestamp":1792090012349,"version":"4.4.0"},"reference-count":86,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part B: Reviews"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>The standard for long-segment reconstruction of the ureter and urinary diversion is the creation of neotissue using autologous bowel tissue, although associated with multiple complications. Tissue-engineered constructs may provide alternative solutions. In this study, we review ureter reconstruction and urinary diversion using Tissue Engineering approaches. A literature search strategy was applied in PubMed to identify all available preclinical studies published up until September 2018. Subsequently, studies were screened for scaffolds used and relevance (e.g., reconstruction of full circumferential defects in preclinical settings) and further categorized based on whether grafts were directly implanted, seeded with cells before implantation, or preimplanted (with or without cells) before functional implantation. Future prospects are discussed with emphasis on scaffold design and functional tissue maturation of tissue-engineered constructs to foster clinical translation.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Impact Statement<\/jats:title>\n                    <jats:p>Tissue Engineering (TE) approaches are needed to advance the field of reconstructive urology. We indicate that regeneration of ureteral tissue and the formation of a urinary diversion using TE approaches are possible, although it is currently very time-consuming and complex to achieve well-developed neotissue. Faster regeneration approaches using novel scaffolds are desirable. The findings of this review may help to develop smart hybrid scaffolds and enhance the design of future studies, which may ultimately lead to improved care for patients with ureteral defects as well as to curb complications associated with urinary diversion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ten.teb.2018.0345","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T09:45:34Z","timestamp":1550828734000},"page":"237-248","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Reconstruction Strategies of the Ureter and Urinary Diversion Using Tissue Engineering Approaches"],"prefix":"10.1177","volume":"25","author":[{"given":"Heinz P.","family":"Janke","sequence":"first","affiliation":[{"name":"Department of Urology, Radboud Institute for Molecular Life Science, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K.J.D.","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Department of Urology, Radboud Institute for Molecular Life Science, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wout F.J.","family":"Feitz","sequence":"additional","affiliation":[{"name":"Department of Urology, Radboud Institute for Molecular Life Science, Radboud University Medical Center, Nijmegen, The Netherlands."},{"name":"Radboudumc Amalia Children's Hospital, Nijmegen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egbert","family":"Oosterwijk","sequence":"additional","affiliation":[{"name":"Department of Urology, Radboud Institute for Molecular Life Science, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756287214526767"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.05.058"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.07.030"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12508"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.06.020"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3233\/BLC-170162"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2011.147"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493529"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1258\/la.2010.009117"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200802977"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-7021(11)70058-X"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.1999.13.241"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-200005000-00005"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/089419301753170039"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/089277902753483682"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/0892779041271472"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2005.19.1069"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000121437.94629.ef"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.02.092"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.106311"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000134886.44065.00"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00391-9"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106023"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.01.047"},{"key":"e_1_3_4_26_2","first-page":"3757","article-title":"Differentiate into urothelium and smooth muscle cells from adipose tissue-derived stem cells for ureter reconstruction in a rabbit model","volume":"8","author":"Zhao Z.","year":"2016","unstructured":"Zhao Z., , Yu H., , Fan C., , Kong Q., , Liu D., , and Meng L. 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