{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T17:54:24Z","timestamp":1786470864251,"version":"build-2736575974"},"reference-count":142,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part B: Reviews"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>\n                    The recent discovery of mesenchymal stem cells within periapical lesions (PL-MSC) has presented novel opportunities for managing periradicular diseases in adult teeth by way of enhancing tissue regeneration. This discovery coincides with the current paradigm shift toward biologically driven treatment strategies in endodontics, which have typically been reserved for non-vital immature permanent teeth. One such approach that shows promise is utilizing local endogenous non-collagenous dentine extracellular matrix components (dECM) to recruit and upregulate the intrinsic regenerative capacity of PL-MSCs\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    . At picogram levels, these morphogens have demonstrated tremendous ability to enhance the cellular activities in\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    animal studies that would otherwise be necessary for periradicular regeneration. Briefly, these include proliferation, viability, migration, differentiation, and mineralization. Therefore, topical application of dECMs during ortho- or retrograde root canal treatment could potentially enhance and sustain the regenerative mechanisms within diseased periapical tissues that are responsible for attaining favorable clinical and radiographic outcomes. This would provide many advantages when compared with conventional antimicrobial-only therapies for apical periodontitis (AP), which do not directly stimulate healing and have had stagnant success rates over the past five decades despite significant advances in operative techniques. The aim of this narrative review was to present the novel concept of exploiting endogenous dECMs as clinical tools for treating AP in mature permanent teeth. A large scope of literature was summarized to discuss the issues associated with conventional treatment modalities; current knowledge surrounding PL-MSCs; composition of the dECM; inductive potentials of dECM morphogens in other odontogenic stem cell niches; how treatment protocols can be adapted to take advantage of dECMs and PL-MSCs; and finally, the challenges currently impeding successful clinical translation alongside directions for future research.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Impact statement<\/jats:title>\n                    <jats:p>Apical periodontitis (AP) is an inflammatory condition that is associated with a great degree of morbidity and ultimately leads to tooth loss. The purpose of this review was to summarize the current evidence pertaining to stem cell therapy in endodontics and present a novel clinical methodology through which they may be utilized to address AP. A comprehensive overview of the basic science, clinical translation, and potential challenges are presented in this review.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ten.teb.2021.0074","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T11:24:20Z","timestamp":1627298660000},"page":"707-732","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Exploiting Dentine Matrix Proteins in Cell-Free Approaches for Periradicular Tissue Engineering"],"prefix":"10.1177","volume":"28","author":[{"given":"Satnam Singh","family":"Virdee","sequence":"first","affiliation":[{"name":"Institute of Clinical Sciences, School of Dentistry &amp; Birmingham Dental Hospital, University of Birmingham, Birmingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7416-7610","authenticated-orcid":false,"given":"Nasir","family":"Bashir","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, School of Dentistry &amp; Birmingham Dental Hospital, University of Birmingham, Birmingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josette","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, School of Dentistry &amp; Birmingham Dental Hospital, University of Birmingham, Birmingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip L.","family":"Tomson","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, School of Dentistry &amp; Birmingham Dental Hospital, University of Birmingham, Birmingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500604"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.07.028"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07039"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01915.x"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01872.x"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.08.003"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0226"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172687"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509340867"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0031"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.134189"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12954"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.04.009"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2009.0518"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513505772"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.05.019"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16627-0"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0734"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.512"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.05.022"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.02.012"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2008.00410.x"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2012.05.001"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.07.008"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1155\/2000\/31748"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-009-9248-4"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.11.021"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.04.029"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12951"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.12.020"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2010.05.016"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12624"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12588"},{"key":"e_1_3_5_36_2","first-page":"407","article-title":"Dentin matrix component solubilization by solutions of pH relevant to self-etching dental adhesives","volume":"15","author":"Ferracane J.L.","year":"2013","unstructured":"Ferracane J.L., , Cooper P.R., , and Smith A.J. Dentin matrix component solubilization by solutions of pH relevant to self-etching dental adhesives. J Adhes Dent, 15, 407, 2013.","journal-title":"J Adhes Dent"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516653568"},{"key":"e_1_3_5_38_2","first-page":"e278","article-title":"Dentine matrix proteins: isolation and effects on human pulp cells","volume":"51","author":"Widbiller M.","year":"2018","unstructured":"Widbiller M., , Eidt A., , Lindner S.R., et al. Dentine matrix proteins: isolation and effects on human pulp cells. Int Endod J, 51(Suppl 4), e278, 2018.","journal-title":"Int Endod J"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(65)90166-0"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(22)00677-2"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13290"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12877"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.03.009"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12783"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01322.x"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12908"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200402000-00003"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2012.02076.x"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2018.vol32.0065"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1998.t01-1-00111.x"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.07.017"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.05.021"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.06.024"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.01.003"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-003-0832-z"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01917.x"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.6662"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201243010"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515570316"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-016-9674-4"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gien.2018.03.003"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma12040597"},{"key":"e_1_3_5_63_2","first-page":"713","article-title":"Dental pulp stem cells and human periapical cyst mesenchymal stem cells in bone tissue regeneration: comparison of basal and osteogenic differentiated gene expression of a newly discovered mesenchymal stem cell lineage","volume":"29","author":"Tatullo M.","year":"2015","unstructured":"Tatullo M., , Falisi G., , Amantea M., , Rastelli C., , Paduano F., , and Marrelli M. Dental pulp stem cells and human periapical cyst mesenchymal stem cells in bone tissue regeneration: comparison of basal and osteogenic differentiated gene expression of a newly discovered mesenchymal stem cell lineage. J Biol Regul Homeost Agents, 29, 713, 2015.","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.2217\/rme.10.30"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.09.002"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9120358"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr801065s"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2012.00977.x"},{"key":"e_1_3_5_69_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1387\/ijdb.7626404","article-title":"The nature and functional significance of dentin extracellular matrix proteins","volume":"39","author":"Butler W.T.","year":"1995","unstructured":"Butler W.T., , and Ritchie H. The nature and functional significance of dentin extracellular matrix proteins. Int J Dev Biol, 39, 169, 1995.","journal-title":"Int J Dev Biol"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650050708"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2007.04.008"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.11.009"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(00)00075-3"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.08.042"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1998.tb02158.x"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.12.011"},{"key":"e_1_3_5_77_2","unstructured":"Graham L. Smith A.J. Sloan A. and Cooper P.R. Cytokine release from human dentine. J Dent Res 86 2007. Available at: https:\/\/iadr.abstractarchives.com\/abstract\/bsdr07-95046\/cytokine-release-from-human-dentine (accessed June1 2021)."},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200611"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2012.00270.x"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v018a08"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.02.003"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2011.01.001"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2011.05.004"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(75)90012-6"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345790580031701"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115548"},{"key":"e_1_3_5_87_2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1387\/ijdb.1295560","article-title":"Effects of dentin proteins, transforming growth factor beta 1 (TGF beta 1) and bone morphogenetic protein 2 (BMP2) on the differentiation of odontoblast in vitro","volume":"36","author":"B\u00e8gue-Kirn C.","year":"1992","unstructured":"B\u00e8gue-Kirn C., , Smith A.J., , Ruch J.V., et al. Effects of dentin proteins, transforming growth factor beta 1 (TGF beta 1) and bone morphogenetic protein 2 (BMP2) on the differentiation of odontoblast in vitro. Int J Dev Biol, 36, 491, 1992.","journal-title":"Int J Dev Biol"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1177\/2041731415586318"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1290\/0502014.1"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0121"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2012.07.008"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2016.7104"},{"key":"e_1_3_5_93_2","first-page":"10690","article-title":"Dentinogenic effects of extracted dentin matrix components digested with matrix metalloproteinases","volume":"8","author":"Okamoto M.","year":"2018","unstructured":"Okamoto M., , Takahashi Y., , Komichi S., , Cooper P.R., , and Hayashi M. Dentinogenic effects of extracted dentin matrix components digested with matrix metalloproteinases. Sci Reports, 8, 10690, 2018.","journal-title":"Sci Reports"},{"key":"e_1_3_5_94_2","first-page":"123","article-title":"In vivo morphogenetic activity of dentine matrix proteins","volume":"18","author":"Smith A.J.","year":"1990","unstructured":"Smith A.J., , Tobias R.S., , Plant C.G., , Browne R.M., , Lesot H., , and Ruch J.V. In vivo morphogenetic activity of dentine matrix proteins. J Biol Buccale, 18, 123, 1990.","journal-title":"J Biol Buccale"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(95)00069-2"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.02.011"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510364487"},{"key":"e_1_3_5_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.09.007"},{"key":"e_1_3_5_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12492"},{"key":"e_1_3_5_100_2","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2016.vol30.0131"},{"key":"e_1_3_5_101_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510368647"},{"key":"e_1_3_5_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.08.027"},{"key":"e_1_3_5_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(92)90093-N"},{"key":"e_1_3_5_104_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1994.1063"},{"key":"e_1_3_5_105_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1998.00161.x"},{"key":"e_1_3_5_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(99)00007-2"},{"key":"e_1_3_5_107_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790090901"},{"key":"e_1_3_5_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.10.136"},{"key":"e_1_3_5_109_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300802"},{"key":"e_1_3_5_110_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200404000-00005"},{"key":"e_1_3_5_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2007.06.012"},{"key":"e_1_3_5_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2008.03.013"},{"key":"e_1_3_5_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.08.046"},{"key":"e_1_3_5_114_2","first-page":"57","article-title":"Vascular endothelial growth factor enhances in vitro proliferation and osteogenic differentiation of human dental pulp stem cells","volume":"25","author":"d'Alimonte I.","year":"2011","unstructured":"d'Alimonte I., , Nargi E., , Mastrangelo F., et al. Vascular endothelial growth factor enhances in vitro proliferation and osteogenic differentiation of human dental pulp stem cells. J Biol Regul Homeost Agents, 25, 57, 2011.","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_3_5_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.05.002"},{"key":"e_1_3_5_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.10.015"},{"key":"e_1_3_5_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.11.007"},{"key":"e_1_3_5_118_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514525200"},{"key":"e_1_3_5_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(98)00026-0"},{"key":"e_1_3_5_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00121-5"},{"key":"e_1_3_5_121_2","doi-asserted-by":"publisher","DOI":"10.1038\/43474"},{"key":"e_1_3_5_122_2","doi-asserted-by":"publisher","DOI":"10.1159\/000151455"},{"key":"e_1_3_5_123_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509334070"},{"key":"e_1_3_5_124_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1824-1"},{"key":"e_1_3_5_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.03.009"},{"key":"e_1_3_5_126_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510370803"},{"key":"e_1_3_5_127_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0719-2"},{"key":"e_1_3_5_128_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190785"},{"key":"e_1_3_5_129_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0181"},{"key":"e_1_3_5_130_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511408426"},{"key":"e_1_3_5_131_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma14040874"},{"key":"e_1_3_5_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60668-X"},{"key":"e_1_3_5_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.01.014"},{"key":"e_1_3_5_134_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12629"},{"key":"e_1_3_5_135_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13080"},{"key":"e_1_3_5_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.05.013"},{"key":"e_1_3_5_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.07.026"},{"key":"e_1_3_5_138_2","first-page":"32","article-title":"Efficiency of different concentrations of sodium hypochlorite during endodontic treatment. Literature review","volume":"2","author":"Marion J.","year":"2012","unstructured":"Marion J., , Manh\u00e3es F., , Bajo H., , and Duque T. Efficiency of different concentrations of sodium hypochlorite during endodontic treatment. Literature review. Dent Press Endod, 2, 32, 2012.","journal-title":"Dent Press Endod"},{"key":"e_1_3_5_139_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.don.0000148143.80283.ea"},{"key":"e_1_3_5_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.11.017"},{"key":"e_1_3_5_141_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1994.tb00048.x"},{"key":"e_1_3_5_142_2","doi-asserted-by":"publisher","DOI":"10.1258\/la.2009.008120"},{"key":"e_1_3_5_143_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13125"}],"container-title":["Tissue Engineering Part B: Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ten.teb.2021.0074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ten.teb.2021.0074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ten.teb.2021.0074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:02:37Z","timestamp":1777698157000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ten.teb.2021.0074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":142,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1089\/ten.teb.2021.0074"],"URL":"https:\/\/doi.org\/10.1089\/ten.teb.2021.0074","relation":{},"ISSN":["1937-3368","1937-3376"],"issn-type":[{"value":"1937-3368","type":"print"},{"value":"1937-3376","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]}}}