{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:45:44Z","timestamp":1782881144949,"version":"3.54.5"},"reference-count":55,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part B: Reviews"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Ischemic heart disease, a major risk factor for myocardial infarction (MI), occurs when the blood vessels supplying oxygen-rich blood to the heart become partially or fully occluded by lipid-rich plaques, resulting in myocardial cell death, remodeling, and scarring. In addition, MI occurs as result of lipid-rich plaque rupture, resulting in thrombosis and vessel occlusion. Cardiac fibroblasts (CFs) and CF-derived growth factors are crucial post-MI in myocardial remodeling. Information regarding the regenerative phenotypes of CFs is scarce; however, regenerative CFs are translationally relevant in myocardial regeneration following MI. The emerging technologies in regenerative cardiology offer cutting-edge translational opportunities, including synthetic cells. In this review, we critically reviewed the current knowledge and the ongoing research efforts on application of synthetic cells for improving cardiac regeneration post-MI.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Impact statement<\/jats:title>\n                    <jats:p>Synthetic cells offer tremendous regenerative potential in otherwise deleterious cardiac remodeling postmyocardial infarction. Understanding the role of fibroblasts in cardiac healing and the therapeutic applications of synthetic cells would open a multitude of novel cardiac regenerative approaches. The novel concept of synthetic fibroblasts that emulate native cardiac fibroblasts can provide an effective solution in cardiac healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ten.teb.2022.0050","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T07:50:45Z","timestamp":1652169045000},"page":"1235-1241","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthetic Fibroblasts: Terra Incognita in Cardiac Regeneration"],"prefix":"10.1177","volume":"28","author":[{"given":"Albert","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Translational Research, Western University of Health Sciences, Pomona, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Translational Research, Western University of Health Sciences, Pomona, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-0013","authenticated-orcid":false,"given":"Devendra K.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Translational Research, Western University of Health Sciences, Pomona, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9366-6204","authenticated-orcid":false,"given":"Huinan Hannah","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of California, Riverside, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmini","family":"Varadarajan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, University of California Riverside, Riverside, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-4566","authenticated-orcid":false,"given":"Ramdas","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, University of California Riverside, Riverside, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7285-9808","authenticated-orcid":false,"given":"Finosh G.","family":"Thankam","sequence":"additional","affiliation":[{"name":"Department of Translational Research, Western University of Health Sciences, Pomona, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"CDC. 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